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A8FKS9 (HEMH_CAMJ8) Reviewed, UniProtKB/Swiss-Prot

Last modified August 10, 2010. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
Customize displayNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Protoheme ferro-lyase
Heme synthase
Gene names
Name:hemH
Ordered Locus Names:C8J_0467
OrganismCampylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828) [Complete proteome] [HAMAP]
Taxonomic identifier407148 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Ferrochelatase HAMAP MF_00323
PRO_1000072023

Sites

Metal binding1851Iron By similarity
Metal binding2621Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FKS9-1 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 24E981BDC510B5E2

FASTA30935,723
        10         20         30         40         50         60 
MKLVLFLNMG GATNLQDCEV FLKNMFNDPY ILGIKNRFLR KFVAWIITKA RVKAMQENYK 

        70         80         90        100        110        120 
KMGGKSPLNE LTQSLCNKLN LKQDEFKFDF VNLYVPPFAT EILQKYTLNE SDEIILFPLY 

       130        140        150        160        170        180 
PHHSCTTVTS SLEVLQNEIS KQKIQAKVKT IDIFYKNELY NEMIVSHILA KKSKFDAKIL 

       190        200        210        220        230        240 
IFSAHSLPQS IIDKGDLYEK HVNDHVEILK EKLKDHFDEF ILAYQSKLGP VKWLEPNTSD 

       250        260        270        280        290        300 
VLANLNDKAL IYPISFCIDC SETIFELGME YKHLAKCDYD LISCPNDSDE FMEFILNSIN 


SPLARKTSC

« Hide

References

[1]"The complete genome sequence of Campylobacter jejuni strain 81116 (NCTC11828)."
Pearson B.M., Gaskin D.J.H., Segers R.P.A.M., Wells J.M., Nuijten P.J.M., van Vliet A.H.M.
J. Bacteriol. 189:8402-8403(2007) [PubMed: 17873037] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000814 Genomic DNA. Translation: ABV52066.1.
RefSeqYP_001482043.1.

3D structure databases

ProteinModelPortalA8FKS9.
SMRA8FKS9. Positions 3-305.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8FKS9.

Genome annotation databases

GeneID5617946.
GenomeReviewsGene locus C8J_0467 in contig CP000814_GR.
KEGGcju:C8J_0467.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMADEFMEFI.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycCJEJ407148:C8J_0467-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. hemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_CAMJ8
AccessionPrimary (citable) accession number: A8FKS9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 13, 2007
Last modified: August 10, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents