A8FK16 (ARGB_CAMJ8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	C8J_0204

Organism

Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828) [Complete proteome] [HAMAP]

Taxonomic identifier

407148 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter jejuni › Campylobacter jejuni subsp. jejuni

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP-Rule MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP-Rule MF_00082
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Acetylglutamate kinase HAMAP-Rule MF_00082		PRO_1000071216
Regions
	Region	64 – 65	2	Substrate binding By similarity
Sites
	Binding site	86	1	Substrate By similarity
	Binding site	177	1	Substrate By similarity
	Site	29	1	Transition state stabilizer By similarity
	Site	238	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8FK16 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 24F884021F110793	FASTA	279	30,553
	10 20 30 40 50 60 MQKYLEKANV LIEALPYIRK FNSKIILIKY GGSAMENEEL KHCVMQDIAL LKLVGLKPII 70 80 90 100 110 120 VHGGGKDISA MCEKLGVKSE FKNGLRVSDK ATTEVASMVL NHINKNLVHS LQNLGVKAIG 130 140 150 160 170 180 LCGKDGALLE CVKKDENLAF VGTIQKVNSK ILEELLEKDF LPIITPIGMD ENFNTYNINA 190 200 210 220 230 240 DDAACSIAKA LRAEKLAFLT DTAGLYEDFN DKNSLISKIS LEQAKILAPK IEGGMHVKLK 250 260 270 SCIDACENGV KKVHILDGRV KHSLLLEFFT DEGIGTLVG

References

[1]

"The complete genome sequence of Campylobacter jejuni strain 81116 (NCTC11828)." Pearson B.M., Gaskin D.J.H., Segers R.P.A.M., Wells J.M., Nuijten P.J.M., van Vliet A.H.M. J. Bacteriol. 189:8402-8403(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 81116 / NCTC 11828.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000814 Genomic DNA. Translation: ABV51803.1.
RefSeq	YP_001481780.1. NC_009839.1.
3D structure databases
ProteinModelPortal	A8FK16.
ModBase	Search...
Protein-protein interaction databases
STRING	407148.C8J_0204.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV51803; ABV51803; C8J_0204.
GeneID	5618110.
KEGG	cju:C8J_0204.
PATRIC	20053968. VBICamJej119085_0207.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HOG000233259.
KO	K00930.
OMA	GNMVFAE.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	CJEJ407148:GHCS-248-MONOMER.
UniPathway	UPA00068; UER00107.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit.
HAMAP	MF_00082_B. ArgB_B.
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_CAMJ8

Accession

Primary (citable) accession number: A8FK16

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program