Reviewed, UniProtKB/Swiss-Prot A8FJT9 (KHSE_CAMJ8)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	C8J_0127

Organism

Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828) [Complete proteome] [HAMAP]

Taxonomic identifier

407148 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Homoserine kinase HAMAP MF_00384		PRO_1000072188
Regions
	Nucleotide binding	84 – 94	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A8FJT9-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 4D71FC11751720F8	FASTA	292	32,520
	10 20 30 40 50 60 MKILVPATSA NLGPGFDCLG LSLKLFNETQ IQKSGVFSIS IGGEGSDNIF LKKNNIFVNI 70 80 90 100 110 120 FYEIYEKLSG KKDNFRFIFQ NNIPLSRGLG SSSAVIVGAI ASAYYMSGFK VEKERILDEA 130 140 150 160 170 180 LIYENHPDNI APATLGGFVC SLVEKNKVYS IKKEIDKDLA AVVVIPNLAM STEQSRQALA 190 200 210 220 230 240 KNLSFNDAVF NLSHASFLTA CFLEKKYEFL KFASQDKLHE INRMKNLPEL FEVQKFALEN 250 260 270 280 290 KALMSTLSGS GSSFFSLAFK DDALALAKKM QTKFKDFCVQ YLEFDDNGFE IC

References

[1]	"The complete genome sequence of Campylobacter jejuni strain 81116 (NCTC11828)." Pearson B.M., Gaskin D.J.H., Segers R.P.A.M., Wells J.M., Nuijten P.J.M., van Vliet A.H.M. J. Bacteriol. 189:8402-8403(2007) [PubMed: 17873037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000814 Genomic DNA. Translation: ABV51726.1.
RefSeq	YP_001481703.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8FJT9.
Genome annotation databases
GeneID	5617654.
GenomeReviews	Gene locus C8J_0127 in contig CP000814_GR.
KEGG	cju:C8J_0127.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NHPDNIT.
Family and domain databases
HAMAP	MF_00384. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR006203. GHMP_knse_ATP_bd_CS. IPR000870. Homoserine_kin. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
TIGRFAMs	TIGR00191. thrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_CAMJ8

Accession

Primary (citable) accession number: A8FJT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)