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A8FIR7 (THIM_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:BPUM_3484
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_1000058758

Sites

Binding site451Substrate; via amide nitrogen By similarity
Binding site1211ATP By similarity
Binding site1681ATP By similarity
Binding site1951Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FIR7 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 8AF7EBBAD1C4F9FB

FASTA27128,236
        10         20         30         40         50         60 
MKTSIASHLL EKVRAENPLV HNITNQVVTN FTANGLLALG ASPVMANAKE EVAEMAQLAD 

        70         80         90        100        110        120 
ALVLNIGTLT KETVESMILA GQSANKKGIP VLLDPVGVGA TTFRLKAAKQ LLEQVNITVV 

       130        140        150        160        170        180 
RGNAAEIAHL LEVDGWESKG VDAKAANGDV SALVKQAAKT LQTVVVITGE VDVVSDGEDV 

       190        200        210        220        230        240 
LSIHNGHEWL TKVTGTGCLL TSVIGAFCAA GERPLHASAA ALLFYGVAAE KAAQYTQNKG 

       250        260        270 
PGTFQMELLN ALSHTTGNDV LTLGKIGRNV T 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000813 Genomic DNA. Translation: ABV64134.1.
RefSeqYP_001488694.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FIR7.
SMRA8FIR7. Positions 1-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315750.BPUM_3484.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV64134; ABV64134; BPUM_3484.
GeneID5622779.
KEGGbpu:BPUM_3484.
PATRIC18970938. VBIBacPum16546_3538.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycBPUM315750:GH6N-3566-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_BACP2
AccessionPrimary (citable) accession number: A8FIR7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways