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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi825ZincUniRule annotation1
Metal bindingi827ZincUniRule annotation1
Metal bindingi836ZincUniRule annotation1
Metal bindingi837ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBPUM315750:G1G9U-3232-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:BPUM_3178
OrganismiBacillus pumilus (strain SAFR-032)
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001355 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003183191 – 841Protein translocase subunit SecAAdd BLAST841

Proteomic databases

PRIDEiA8FHW5

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi315750.BPUM_3178

Structurei

3D structure databases

ProteinModelPortaliA8FHW5
SMRiA8FHW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0653 LUCA
HOGENOMiHOG000218169
KOiK03070
OMAiFEYDEVM
OrthoDBiPOG091H01RS

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR004027 SEC_C_motif
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF02810 SEC-C, 1 hit
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 2 hits
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

A8FHW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGILNKVFD PTKRTISKYE KKANEIEALA QDFEKLSDEA LRNKTIEFKE
60 70 80 90 100
KLEKGQSVDD LLVEAFATVR EASRRVTGMF PFKVQLMGGI ALHEGNISEM
110 120 130 140 150
KTGEGKTLTS TMPVYLNALS GKGVHIVTVN EYLASRDAEE MGKIFEFLGL
160 170 180 190 200
TVGLNLNSLD KDEKREAYAA DITYSTNNEL GFDYLRDNMV LYKEQMVQRP
210 220 230 240 250
LHYAVIDEVD SILIDEARTP LIISGQAAKS TKLYVQANAF VRTLKIEDDF
260 270 280 290 300
TYDIKTKSVQ LTESGMTKAE KAFGIENLFD VKHVALNHHI AQALKAHVAM
310 320 330 340 350
QKDVDYVVEE GQVVIVDSFT GRLMKGRRYS EGLHQAIEAK EGLEVQNESM
360 370 380 390 400
TLATITFQNY FRMYEKLSGM TGTAKTEEEE FRNIYNMQVV TIPTNQPVVR
410 420 430 440 450
DDRPDLIYRT MEGKFKAVAE DVAQRYMTGQ PVLVGTVAVE TSELISKLLK
460 470 480 490 500
NKGIPHQVLN AKNHEREAQI IEEAGQKGAV TIATNMAGRG TDIKLGEGVK
510 520 530 540 550
ELGGLAVIGT ERHESRRIDN QLRGRSGRQG DPGITQFYLS MEDELMRRFG
560 570 580 590 600
AERTMAMLDR FGMDDTTPIQ SKMVSKAVES SQKRVEGNNF DSRKQLLQYD
610 620 630 640 650
DVLRQQREVI YKQRFEVIDS DNLKSIVINM IQSSIERAVG SYTPKEELPE
660 670 680 690 700
EWKLDGLVEL INTNYLDEGA ISVKDIYGKE ADEITSFIMD RIKEKYDAKE
710 720 730 740 750
ETYGDEQMRE FEKVIVLRAV DSKWMDHIDA MDQLRQGIHL RAYAQTNPLR
760 770 780 790 800
EYQMEGFAMF EHMVASIEDD VAKYVLKSEI QNNLEREEVV QGQTTAHQPQ
810 820 830 840
EGDEEKTVKK KPVRKVVDIG RNSPCHCGSG KKYKNCHGKT E
Length:841
Mass (Da):95,346
Last modified:November 13, 2007 - v1
Checksum:iC0931745DCFA932A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000813 Genomic DNA Translation: ABV63832.1
RefSeqiWP_012011417.1, NC_009848.4

Genome annotation databases

EnsemblBacteriaiABV63832; ABV63832; BPUM_3178
KEGGibpu:BPUM_3178

Similar proteinsi

Entry informationi

Entry nameiSECA_BACP2
AccessioniPrimary (citable) accession number: A8FHW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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