A8FH11 (FENR2_BACP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferredoxin--NADP reductase 2
Short name=FNR 2
Short name=Fd-NADP(+) reductase 2
EC=1.18.1.2

Gene names

Ordered Locus Names:

BPUM_2873

Organism

Bacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]

Taxonomic identifier

315750 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus pumilus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP-Rule MF_01685
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	NADP binding Inferred from electronic annotation. Source: HAMAP ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: HAMAP flavin adenine dinucleotide binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Ferredoxin--NADP reductase 2 HAMAP-Rule MF_01685		PRO_0000364800
Sites
	Binding site	37	1	FAD By similarity
	Binding site	45	1	FAD By similarity
	Binding site	50	1	FAD By similarity
	Binding site	90	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	124	1	FAD; via amide nitrogen By similarity
	Binding site	285	1	FAD By similarity
	Binding site	326	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8FH11 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 04E290F6169215D0	FASTA	332	36,743
	10 20 30 40 50 60 MQEDSKVYDI TVIGGGPVGL FTAFYGGMRQ ASVKIIESLP QLGGQLSALY PEKYIYDVAG 70 80 90 100 110 120 FPKIRAQELV DNLKEQMDKF DQTICLEQAV ETVEKQADGI FKLVTNQEIH YSKTIIITAG 130 140 150 160 170 180 NGAFQPRKLE LDAAESFEGS NLHYFINDLN QFAGRRVAVL GGGDSAVDWA LMLEPIAKEV 190 200 210 220 230 240 SIIHRRDKFR AHEHSVENLH NSKVNVVTPF VPTELIGEDR IEQIVLEEVK GDKKQVLDVD 250 260 270 280 290 300 DVIVNFGFVS SLGPIKQWGL EIEKNSIVVK STMETNIEGF YAAGDICTYE GKVKLIASGF 310 320 330 GEAPTAVNNA KAYMDPKARV QPLHSTSLFE NK

References

[1]

"Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032." Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C. , Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K., Weinstock G.M. PLoS ONE 2:E928-E928(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SAFR-032.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000813 Genomic DNA. Translation: ABV63528.1.
RefSeq	YP_001488088.1. NC_009848.1.
3D structure databases
ProteinModelPortal	A8FH11.
ModBase	Search...
Protein-protein interaction databases
STRING	315750.BPUM_2873.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV63528; ABV63528; BPUM_2873.
GeneID	5622167.
KEGG	bpu:BPUM_2873.
PATRIC	18969736. VBIBacPum16546_2938.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0492.
HOGENOM	HOG000072909.
KO	K00384.
OMA	WALMLEP.
ProtClustDB	CLSK2460953.
Enzyme and pathway databases
BioCyc	BPUM315750:GH6N-2959-MONOMER.
Family and domain databases
HAMAP	MF_01685. FENR2.
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR022890. Fd--NADP_Rdtase_type_2. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProtoNet	Search...

Entry information

Entry name

FENR2_BACP2

Accession

Primary (citable) accession number: A8FH11

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program