A8FGU0 (G6PI_BACP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	BPUM_2802

Organism

Bacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]

Taxonomic identifier

315750 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 451	451	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000060392
Sites
	Active site	290	1	Proton donor By similarity
	Active site	311	1	By similarity
	Active site	425	1	By similarity
Amino acid modifications
	Modified residue	38	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8FGU0 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: ED6258A3AF7FB3E2	FASTA	451	50,515
	10 20 30 40 50 60 MTHIQFDYSK ALPFFQEHEL TYLKDFVKVA HHNIHEQTGT GSDYLGWVDL PKQYDREEFA 70 80 90 100 110 120 RIKKSADKIK SDSDVLLVVG IGGSYLGARA AIEFLNHSFY NTLPKGKRKT PQIIFIGNNI 130 140 150 160 170 180 SSSYLTDVMD LLEDADFSIN VISKSGTTTE PAIAFRIFKK LLIEKYGAEE AKKRIYATTD 190 200 210 220 230 240 KARGALKTLA TEEGYESFII PDDVGGRYSV LTAVGLLPIA VSGADIDQMM EGAAKASEDF 250 260 270 280 290 300 ASSELSENAA YQYAVVRNVL YNKGRTIEML INYEPGLQYF AEWWKQLFGE SEGKDEKGIY 310 320 330 340 350 360 PSSANFSTDL HSLGQYVQEG RRDLFETIVN VDKPRHELVI EAEEQDLDGL NYLAGKTVDF 370 380 390 400 410 420 VNKKAFEGTM LAHTDGKVPN LIVTIPEMDA YTFGYLVYFF EKACAMSGYL LGVNPFDQPG 430 440 450 VEAYKVNMFA LLGKPGFEEK KAELESRLKQ S

References

[1]

"Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032." Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C. , Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K., Weinstock G.M. PLoS ONE 2:E928-E928(2007) [PubMed: 17895969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SAFR-032.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000813 Genomic DNA. Translation: ABV63457.1.
RefSeq	YP_001488017.1. NC_009848.1.
3D structure databases
ProteinModelPortal	A8FGU0.
SMR	A8FGU0. Positions 4-448.
ModBase	Search...
Protein-protein interaction databases
STRING	A8FGU0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000064883; EBBACP00000063216; EBBACG00000064874.
GeneID	5622096.
GenomeReviews	Gene locus BPUM_2802 in contig CP000813_GR.
KEGG	bpu:BPUM_2802.
PATRIC	18969594. VBIBacPum16546_2867.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
GeneTree	EBGT00050000001561.
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	BPUM315750:BPUM_2802-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_BACP2

Accession

Primary (citable) accession number: A8FGU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program