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A8FG70

- ASSY_BACP2

UniProt

A8FG70 - ASSY_BACP2

Protein

Argininosuccinate synthase

Gene

argG

Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871CitrullineUniRule annotation
    Binding sitei117 – 1171ATP; via amide nitrogenUniRule annotation
    Binding sitei119 – 1191AspartateUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei123 – 1231CitrullineUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei127 – 1271CitrullineUniRule annotation
    Binding sitei175 – 1751CitrullineUniRule annotation
    Binding sitei184 – 1841CitrullineUniRule annotation
    Binding sitei260 – 2601CitrullineUniRule annotation
    Binding sitei272 – 2721CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPUM315750:GH6N-2635-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:BPUM_2577
    OrganismiBacillus pumilus (strain SAFR-032)
    Taxonomic identifieri315750 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001355: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Argininosuccinate synthasePRO_1000057037Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315750.BPUM_2577.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FG70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8FG70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQNKKVVLA YSGGLDTSVA VKWLQEQGYE VVACCLDVGE GKDLAFVQQK    50
    ALQVGAVQSY MIDAKEEFAE EFALTALQAH TMYEGKYPLV SALSRPLIAK 100
    KLVEVAEKEN AVAVAHGCTG KGNDQVRFEV SIKALNPDLE VLAPVREWKW 150
    SRDEEIDYAQ KHGIPIPINL DSPYSIDQNL WGRSNECGIL EDPWAAPPEG 200
    AYDLTTPLEK TPDTPEIIEI TFEKGKPTAI DGIQYSLSDL ILHLNEVAGQ 250
    HGVGRIDHVE NRLVGIKSRE VYECPGAVTL LKAHKELEDL TLVKEVAHFK 300
    PIVEQKMAEL IYNGLWFSPL KGALDAFLQE TQQNVTGVVR VKLFKGHAIV 350
    EGRKSPYSLY DENLATYTKA DEFDHDAAVG FINLWGLPTK VNSIVNKKEQ 400
    VKA 403
    Length:403
    Mass (Da):44,670
    Last modified:November 13, 2007 - v1
    Checksum:iEDE3F168722362AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000813 Genomic DNA. Translation: ABV63237.1.
    RefSeqiYP_001487797.1. NC_009848.1.

    Genome annotation databases

    EnsemblBacteriaiABV63237; ABV63237; BPUM_2577.
    GeneIDi5621847.
    KEGGibpu:BPUM_2577.
    PATRICi18969080. VBIBacPum16546_2634.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000813 Genomic DNA. Translation: ABV63237.1 .
    RefSeqi YP_001487797.1. NC_009848.1.

    3D structure databases

    ProteinModelPortali A8FG70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315750.BPUM_2577.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV63237 ; ABV63237 ; BPUM_2577 .
    GeneIDi 5621847.
    KEGGi bpu:BPUM_2577.
    PATRICi 18969080. VBIBacPum16546_2634.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci BPUM315750:GH6N-2635-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SAFR-032.

    Entry informationi

    Entry nameiASSY_BACP2
    AccessioniPrimary (citable) accession number: A8FG70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3