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A8FG70

- ASSY_BACP2

UniProt

A8FG70 - ASSY_BACP2

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871CitrullineUniRule annotation
Binding sitei117 – 1171ATP; via amide nitrogenUniRule annotation
Binding sitei119 – 1191AspartateUniRule annotation
Binding sitei123 – 1231AspartateUniRule annotation
Binding sitei123 – 1231CitrullineUniRule annotation
Binding sitei124 – 1241AspartateUniRule annotation
Binding sitei127 – 1271CitrullineUniRule annotation
Binding sitei175 – 1751CitrullineUniRule annotation
Binding sitei184 – 1841CitrullineUniRule annotation
Binding sitei260 – 2601CitrullineUniRule annotation
Binding sitei272 – 2721CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPUM315750:GH6N-2635-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:BPUM_2577
OrganismiBacillus pumilus (strain SAFR-032)
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001355: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Argininosuccinate synthasePRO_1000057037Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi315750.BPUM_2577.

Structurei

3D structure databases

ProteinModelPortaliA8FG70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8FG70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQNKKVVLA YSGGLDTSVA VKWLQEQGYE VVACCLDVGE GKDLAFVQQK
60 70 80 90 100
ALQVGAVQSY MIDAKEEFAE EFALTALQAH TMYEGKYPLV SALSRPLIAK
110 120 130 140 150
KLVEVAEKEN AVAVAHGCTG KGNDQVRFEV SIKALNPDLE VLAPVREWKW
160 170 180 190 200
SRDEEIDYAQ KHGIPIPINL DSPYSIDQNL WGRSNECGIL EDPWAAPPEG
210 220 230 240 250
AYDLTTPLEK TPDTPEIIEI TFEKGKPTAI DGIQYSLSDL ILHLNEVAGQ
260 270 280 290 300
HGVGRIDHVE NRLVGIKSRE VYECPGAVTL LKAHKELEDL TLVKEVAHFK
310 320 330 340 350
PIVEQKMAEL IYNGLWFSPL KGALDAFLQE TQQNVTGVVR VKLFKGHAIV
360 370 380 390 400
EGRKSPYSLY DENLATYTKA DEFDHDAAVG FINLWGLPTK VNSIVNKKEQ

VKA
Length:403
Mass (Da):44,670
Last modified:November 13, 2007 - v1
Checksum:iEDE3F168722362AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV63237.1.
RefSeqiYP_001487797.1. NC_009848.1.

Genome annotation databases

EnsemblBacteriaiABV63237; ABV63237; BPUM_2577.
GeneIDi5621847.
KEGGibpu:BPUM_2577.
PATRICi18969080. VBIBacPum16546_2634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV63237.1 .
RefSeqi YP_001487797.1. NC_009848.1.

3D structure databases

ProteinModelPortali A8FG70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315750.BPUM_2577.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV63237 ; ABV63237 ; BPUM_2577 .
GeneIDi 5621847.
KEGGi bpu:BPUM_2577.
PATRICi 18969080. VBIBacPum16546_2634.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci BPUM315750:GH6N-2635-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAFR-032.

Entry informationi

Entry nameiASSY_BACP2
AccessioniPrimary (citable) accession number: A8FG70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3