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A8FG69 (ARLY_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:BPUM_2576
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Argininosuccinate lyase HAMAP MF_00006
PRO_1000057047

Sequences

Sequence LengthMass (Da)Tools
A8FG69 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 2F8FCCB7973A7F89

FASTA45751,662
        10         20         30         40         50         60 
MKKLWGGRFQ KTPEKWVDEF GASIHFDKQL VKEDLTGSLA HASMLNTCGI LDDEEAATIK 

        70         80         90        100        110        120 
DGLNKLMKKA EADELEFSVD YEDIHLNLEK MLIDEIGPLG GKLHTARSRN DQVATDMHLY 

       130        140        150        160        170        180 
LNNQVEHIIE LISSFQTVLV EKAEQHVETI FPGYTHLQRA QPISFAHHML AYFWMLERDK 

       190        200        210        220        230        240 
ARFQDSLKRI NVSPLGCGAL AGTTFPIDRE YTAELLGFDH IYENSLDGVS DRDFILEFLS 

       250        260        270        280        290        300 
NSSLVMMHLS RLCEEIILWC SQEFKFIELD DTYATGSSMM PQKKNPDMAE LIRGKTGRVY 

       310        320        330        340        350        360 
GNLMGLLTIM KGLPLTYNKD LQEDKEGMFD TVKTIAGSLQ IFTGMIQTMT VNEDVMKKAT 

       370        380        390        400        410        420 
KEDFSNATEV ADYLAKKGMP FREAHEIVGK LVYTCIQEGI YLSDLPFETF TEASDLFEED 

       430        440        450 
IYTVLDPYVA VEKRTSAGGT GFKQIQLALE KAKACLA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV63236.1.
RefSeqYP_001487796.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FG69.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8FG69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000063605; EBBACP00000061938; EBBACG00000063596.
GeneID5621846.
GenomeReviewsGene locus BPUM_2576 in contig CP000813_GR.
KEGGbpu:BPUM_2576.
PATRIC18969078. VBIBacPum16546_2633.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
GeneTreeEBGT00070000031828.
HOGENOMHBG539632.
OMAEDIHTVI.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_2576-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_BACP2
AccessionPrimary (citable) accession number: A8FG69
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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