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A8FFW6 (ILVC_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:BPUM_2470
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000060226

Sites

Active site1071 Potential

Sequences

Sequence LengthMass (Da)Tools
A8FFW6 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 6F09EA8918463B77

FASTA34237,507
        10         20         30         40         50         60 
MVKVYYNGDI QENVLNGQKV AIIGYGSQGH AHALNLKESG VDVIVGVRKG GSYTKAQEDG 

        70         80         90        100        110        120 
HQVFTVKEAA AQADVLMVLL PDEQQKKVYD EEIKDQLEAG NSLVFAHGFN VHFHQIVPPS 

       130        140        150        160        170        180 
DVDVYLVAPK GPGHLVRRTY EQGAGVPALF AIYQDVSGQA KDKALAYAKA IGGARAGVLE 

       190        200        210        220        230        240 
TTFKEETETD LFGEQAVLCG GLTSLVKAGF ETLTEAGYQP ELAYFECLHE LKLIVDLMYE 

       250        260        270        280        290        300 
EGLEGMRYSI SDTAQWGDFV SGPRVVDANV KESMKAVLTD IQNGTFAKEW IVENQVNRPR 

       310        320        330        340 
FNAINANENE HQIEVVGRKL REMMPFVKQG KKKEAVSVGA EN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV63133.1.
RefSeqYP_001487693.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FFW6.
SMRA8FFW6. Positions 2-327.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8FFW6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000065768; EBBACP00000064101; EBBACG00000065759.
GeneID5621739.
GenomeReviewsGene locus BPUM_2470 in contig CP000813_GR.
KEGGbpu:BPUM_2470.
PATRIC18968862. VBIBacPum16546_2526.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
GeneTreeEBGT00050000000943.
HOGENOMHBG286525.
OMAMAYAKGI.
ProtClustDBPRK05479.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_2470-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_BACP2
AccessionPrimary (citable) accession number: A8FFW6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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