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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciBPUM315750:G1G9U-2242-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:BPUM_2188
OrganismiBacillus pumilus (strain SAFR-032)
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001355 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000620791 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PRIDEiA8FF40

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi315750.BPUM_2188

Structurei

3D structure databases

ProteinModelPortaliA8FF40
SMRiA8FF40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A8FF40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHRYLPQTE QDQKEMLDVI GVQSIDELFS DIPEKVRFKG AYNIKPAASE
60 70 80 90 100
TELVRELSQL AAKNKDTVSY ASFLGAGVYD HYQPVIVDHV ISRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MIAELTGMDL ANSSMYDGGT ALAEAAMLAA
160 170 180 190 200
GHTKKKKVVV SETVHPEARA VLKTYAKGQH IEVVEVPAKK GQTDLAALEK
210 220 230 240 250
AVCDETAAVL VQYPNFFGVV EPLKDIEPIA HKGKSLFVVS SNPLALGLLT
260 270 280 290 300
PPGKLGADIV VGDAQPFGIP AAFGGPHCGY FAVTKKLMRK VPGRLVGQTE
310 320 330 340 350
DENGVRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VAMTALGKTG
360 370 380 390 400
IKDIAYQNVQ KAHYAKTQAE TYGLLADVEG THFNEFVIKL QEPVQEVNKR
410 420 430 440
LLEKGIIGGY DLGRDYPELQ HHMLVAVTEL RTKEEIDTFI KELGDRHE
Length:448
Mass (Da):49,168
Last modified:November 13, 2007 - v1
Checksum:i960C81617A212877
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000813 Genomic DNA Translation: ABV62857.1
RefSeqiWP_012010551.1, NC_009848.4

Genome annotation databases

EnsemblBacteriaiABV62857; ABV62857; BPUM_2188
KEGGibpu:BPUM_2188

Entry informationi

Entry nameiGCSPA_BACP2
AccessioniPrimary (citable) accession number: A8FF40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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