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A8FF40 (GCSPA_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:BPUM_2188
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000062079

Sequences

Sequence LengthMass (Da)Tools
A8FF40 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 960C81617A212877

FASTA44849,168
        10         20         30         40         50         60 
MKHRYLPQTE QDQKEMLDVI GVQSIDELFS DIPEKVRFKG AYNIKPAASE TELVRELSQL 

        70         80         90        100        110        120 
AAKNKDTVSY ASFLGAGVYD HYQPVIVDHV ISRSEFYTAY TPYQPEISQG ELQAIFEFQT 

       130        140        150        160        170        180 
MIAELTGMDL ANSSMYDGGT ALAEAAMLAA GHTKKKKVVV SETVHPEARA VLKTYAKGQH 

       190        200        210        220        230        240 
IEVVEVPAKK GQTDLAALEK AVCDETAAVL VQYPNFFGVV EPLKDIEPIA HKGKSLFVVS 

       250        260        270        280        290        300 
SNPLALGLLT PPGKLGADIV VGDAQPFGIP AAFGGPHCGY FAVTKKLMRK VPGRLVGQTE 

       310        320        330        340        350        360 
DENGVRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VAMTALGKTG IKDIAYQNVQ 

       370        380        390        400        410        420 
KAHYAKTQAE TYGLLADVEG THFNEFVIKL QEPVQEVNKR LLEKGIIGGY DLGRDYPELQ 

       430        440 
HHMLVAVTEL RTKEEIDTFI KELGDRHE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000813 Genomic DNA. Translation: ABV62857.1.
RefSeqYP_001487417.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FF40.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315750.BPUM_2188.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV62857; ABV62857; BPUM_2188.
GeneID5621457.
KEGGbpu:BPUM_2188.
PATRIC18968278. VBIBacPum16546_2235.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycBPUM315750:GH6N-2245-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_BACP2
AccessionPrimary (citable) accession number: A8FF40
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families