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A8FF40

- GCSPA_BACP2

UniProt

A8FF40 - GCSPA_BACP2

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, BPUM_2188
Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciBPUM315750:GH6N-2245-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:BPUM_2188
OrganismiBacillus pumilus (strain SAFR-032)
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001355: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000062079Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi315750.BPUM_2188.

Structurei

3D structure databases

ProteinModelPortaliA8FF40.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FF40-1 [UniParc]FASTAAdd to Basket

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MKHRYLPQTE QDQKEMLDVI GVQSIDELFS DIPEKVRFKG AYNIKPAASE    50
TELVRELSQL AAKNKDTVSY ASFLGAGVYD HYQPVIVDHV ISRSEFYTAY 100
TPYQPEISQG ELQAIFEFQT MIAELTGMDL ANSSMYDGGT ALAEAAMLAA 150
GHTKKKKVVV SETVHPEARA VLKTYAKGQH IEVVEVPAKK GQTDLAALEK 200
AVCDETAAVL VQYPNFFGVV EPLKDIEPIA HKGKSLFVVS SNPLALGLLT 250
PPGKLGADIV VGDAQPFGIP AAFGGPHCGY FAVTKKLMRK VPGRLVGQTE 300
DENGVRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VAMTALGKTG 350
IKDIAYQNVQ KAHYAKTQAE TYGLLADVEG THFNEFVIKL QEPVQEVNKR 400
LLEKGIIGGY DLGRDYPELQ HHMLVAVTEL RTKEEIDTFI KELGDRHE 448
Length:448
Mass (Da):49,168
Last modified:November 13, 2007 - v1
Checksum:i960C81617A212877
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV62857.1.
RefSeqiWP_012010551.1. NC_009848.1.
YP_001487417.1. NC_009848.1.

Genome annotation databases

EnsemblBacteriaiABV62857; ABV62857; BPUM_2188.
GeneIDi5621457.
KEGGibpu:BPUM_2188.
PATRICi18968278. VBIBacPum16546_2235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV62857.1 .
RefSeqi WP_012010551.1. NC_009848.1.
YP_001487417.1. NC_009848.1.

3D structure databases

ProteinModelPortali A8FF40.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315750.BPUM_2188.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV62857 ; ABV62857 ; BPUM_2188 .
GeneIDi 5621457.
KEGGi bpu:BPUM_2188.
PATRICi 18968278. VBIBacPum16546_2235.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci BPUM315750:GH6N-2245-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAFR-032.

Entry informationi

Entry nameiGCSPA_BACP2
AccessioniPrimary (citable) accession number: A8FF40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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