A8FEK5 (AROC_BACP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BPUM_2002

Organism

Bacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]

Taxonomic identifier

315750 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Chorismate synthase HAMAP MF_00300		PRO_1000059309

Sequences

	Sequence		Length	Mass (Da)
	A8FEK5 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 4D817F82A15DF962	FASTA	390	42,738
	10 20 30 40 50 60 MRYLTAGESH GPQLTTIIEG VPAGLYIEQD DINYELARRQ KGHGRGRRMQ IEKDQAKVLS 70 80 90 100 110 120 GVRHGKTLGS PIALVVENND WKHWTKVMGA EPITEEEESE MKRQISRPRP GHADLNGAIK 130 140 150 160 170 180 YGHRDMRNVL ERSSARETTV RVAAGAVAKQ ILAHLGIKVA GHVLEIGGVK AAHTAYESIE 190 200 210 220 230 240 DLQKVTEESP VRCYDSEAGQ KMMDAIDEAK KNGDSIGGIV EVIVEGMPVG VGSYVHYDRK 250 260 270 280 290 300 LDSKLAGAVL SINAFKGVEF GIGFEAASKN GSEVHDEIIW DEEKGYTRKT NRLGGLEGGM 310 320 330 340 350 360 STGMPIVVRG VMKPIPTLYK PLQSVDIETK EPFSASIERS DSCAVPAASV VAEAVVAWEI 370 380 390 ANAVVEQFGL DQIDRIKENV EKMRQLQREF

References

[1]

"Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032." Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C. , Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K., Weinstock G.M. PLoS ONE 2:E928-E928(2007) [PubMed: 17895969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SAFR-032.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000813 Genomic DNA. Translation: ABV62672.1.
RefSeq	YP_001487232.1. NC_009848.1.
3D structure databases
ProteinModelPortal	A8FEK5.
SMR	A8FEK5. Positions 1-390.
ModBase	Search...
Protein-protein interaction databases
STRING	A8FEK5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000065167; EBBACP00000063500; EBBACG00000065158.
GeneID	5621271.
GenomeReviews	Gene locus BPUM_2002 in contig CP000813_GR.
KEGG	bpu:BPUM_2002.
PATRIC	18967904. VBIBacPum16546_2048.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
GeneTree	EBGT00050000002373.
HOGENOM	HBG292336.
OMA	MLRWLTA.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	BPUM315750:BPUM_2002-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BACP2

Accession

Primary (citable) accession number: A8FEK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program