Reviewed, UniProtKB/Swiss-Prot A8FEK4 (AROB_BACP2)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BPUM_2001

Organism

Bacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]

Taxonomic identifier

315750 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094458

Sequences

	Sequence		Length	Mass (Da)
	A8FEK4-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: DF9AF8FC43CE714C	FASTA	363	40,179
	10 20 30 40 50 60 MKTLEVKTSS ATYPVYIGDG IKRNIVDLMT STGHSYTKLL IVTDTAVDAI YGDEMVRLLE 70 80 90 100 110 120 QKWSVHKVVV PSGEQSKSFA EFEHIHTKAI QFQLDRSSCI IALGGGVIGD LAGFVAASYM 130 140 150 160 170 180 RGIDFIQVPT TLLAHDSAVG GKTGINHPLG KNLIGAFHQP KAVIYDTSML ETLSQTEMRS 190 200 210 220 230 240 GFAEVIKHAL ISSEDFLKEL MSIRSLDECS KSELAHMLYQ GIEVKASIVQ KDEREQGVRA 250 260 270 280 290 300 FLNLGHTLGH AIEAEYGYGV ITHGDAIAIG MQFALYVSEK KLGLSLHRTE LKEWMKKLGF 310 320 330 340 350 360 PVQVTQDIST KTFVDRMIGD KKARGGTVQF VLLKQVGDAV LQSFTKDDLH QWLDEWKREE GCL

References

[1]

"Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032." Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C. , Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K., Weinstock G.M. PLoS ONE 2:E928-E928(2007) [PubMed: 17895969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000813 Genomic DNA. Translation: ABV62671.1.
RefSeq	YP_001487231.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8FEK4.
Genome annotation databases
GeneID	5621270.
GenomeReviews	Gene locus BPUM_2001 in contig CP000813_GR.
KEGG	bpu:BPUM_2001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LGEVIKY.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BACP2

Accession

Primary (citable) accession number: A8FEK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)