Reviewed,
UniProtKB/Swiss-Prot A8FEK0 (TRPC_BACP2)
Last modified
February 9, 2010.
Version 15.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Indole-3-glycerol phosphate synthase Short name=IGPS EC=4.1.1.48 | ||||
| Gene names |
| ||||
| Organism | Bacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 315750 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 250 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134 |
| Pathway | Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134 |
| Sequence similarities | Belongs to the trpC family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis |
| Molecular function | Decarboxylase Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 250 | 250 | Indole-3-glycerol phosphate synthase HAMAP MF_00134 | PRO_1000057871 | |||
Sequences
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References
| [1] | "Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032." Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C.  Weinstock G.M.PLoS ONE 2:E928-E928(2007) [PubMed: 17895969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000813 Genomic DNA. Translation: ABV62667.1. |
| RefSeq | YP_001487227.1. |
3D structure databases | |
| SMR | A8FEK0. Positions 1-249. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A8FEK0. |
Genome annotation databases | |
| GeneID | 5621266. |
| GenomeReviews | Gene locus BPUM_1997 in contig CP000813_GR. |
| KEGG | bpu:BPUM_1997. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0134. |
| HOGENOM | HBG540956. |
| OMA | PLLCKDF. |
Family and domain databases | |
| HAMAP | MF_00134_B. IGPS_B. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF00218. IGPS. 1 hit. [Graphical view] |
| PROSITE | PS00614. IGPS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TRPC_BACP2 | ||||||||
| Accession | Primary (citable) accession number: A8FEK0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
