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A8FEC9

- FTHS_BACP2

UniProt

A8FEC9 - FTHS_BACP2

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, BPUM_1926
Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPUM315750:GH6N-1982-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:BPUM_1926
OrganismiBacillus pumilus (strain SAFR-032)
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001355: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000318564Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315750.BPUM_1926.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8FEC9-1 [UniParc]FASTAAdd to Basket

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MITKHLSDID IAQQAKLRPI QDIAAKLQLH DEELECYGFT KAKISLTIFD    50
RLKEQKEGHV ILVTSINPTP AGEGKSTVTV GLGQAFEKIG KKAIIAMREP 100
SLGPTMGIKG GAAGGGYSQV LPMEEINLHF TGDFHAITSA HNALSAFIDN 150
HIHHGNELDI DARRIVWKRV LDLNDRALRQ VVVGLGGQVN GYPREDGFDI 200
TVASEMMAIL CLAEDLTDLK KRLSSIVVAY NRDGEPVTVG ALGYEGVLTL 250
LLKDALKPNL VQTIEGTPAL VHGGPFANIA HGCNSLIATK MAAKLADYVV 300
TEAGFGADLG AEKFLNIKTR AGDFKPGAVV IVATVRALKM HGGMKKTELK 350
EENTQAVLKG IHNLEKHIET VQAFGLPYIV AVNRFITDTK EEIQAIEDWC 400
LAHDHPVKAV NVWEEGGEGG TALAEELTTL IEKKKNSFSY LYEEDDSIEE 450
KLSKVAKVVY GADGVTLTSK ARKQLAAIEE NSWGHLPVCM AKTQYSLSDD 500
PALIGRPKGF TITIRELKPS VGAGFIVALT GSILTMPGLP KKPAALEMDL 550
LEDGSVTGLF 560
Length:560
Mass (Da):60,467
Last modified:November 13, 2007 - v1
Checksum:i06EBAA5FB9E818FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV62596.1.
RefSeqiYP_001487156.1. NC_009848.1.

Genome annotation databases

EnsemblBacteriaiABV62596; ABV62596; BPUM_1926.
GeneIDi5621194.
KEGGibpu:BPUM_1926.
PATRICi18967748. VBIBacPum16546_1970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV62596.1 .
RefSeqi YP_001487156.1. NC_009848.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315750.BPUM_1926.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV62596 ; ABV62596 ; BPUM_1926 .
GeneIDi 5621194.
KEGGi bpu:BPUM_1926.
PATRICi 18967748. VBIBacPum16546_1970.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BPUM315750:GH6N-1982-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAFR-032.

Entry informationi

Entry nameiFTHS_BACP2
AccessioniPrimary (citable) accession number: A8FEC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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