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A8FEC9 (FTHS_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:BPUM_1926
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000318564

Regions

Nucleotide binding69 – 768ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FEC9 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 06EBAA5FB9E818FB

FASTA56060,467
        10         20         30         40         50         60 
MITKHLSDID IAQQAKLRPI QDIAAKLQLH DEELECYGFT KAKISLTIFD RLKEQKEGHV 

        70         80         90        100        110        120 
ILVTSINPTP AGEGKSTVTV GLGQAFEKIG KKAIIAMREP SLGPTMGIKG GAAGGGYSQV 

       130        140        150        160        170        180 
LPMEEINLHF TGDFHAITSA HNALSAFIDN HIHHGNELDI DARRIVWKRV LDLNDRALRQ 

       190        200        210        220        230        240 
VVVGLGGQVN GYPREDGFDI TVASEMMAIL CLAEDLTDLK KRLSSIVVAY NRDGEPVTVG 

       250        260        270        280        290        300 
ALGYEGVLTL LLKDALKPNL VQTIEGTPAL VHGGPFANIA HGCNSLIATK MAAKLADYVV 

       310        320        330        340        350        360 
TEAGFGADLG AEKFLNIKTR AGDFKPGAVV IVATVRALKM HGGMKKTELK EENTQAVLKG 

       370        380        390        400        410        420 
IHNLEKHIET VQAFGLPYIV AVNRFITDTK EEIQAIEDWC LAHDHPVKAV NVWEEGGEGG 

       430        440        450        460        470        480 
TALAEELTTL IEKKKNSFSY LYEEDDSIEE KLSKVAKVVY GADGVTLTSK ARKQLAAIEE 

       490        500        510        520        530        540 
NSWGHLPVCM AKTQYSLSDD PALIGRPKGF TITIRELKPS VGAGFIVALT GSILTMPGLP 

       550        560 
KKPAALEMDL LEDGSVTGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000813 Genomic DNA. Translation: ABV62596.1.
RefSeqYP_001487156.1. NC_009848.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315750.BPUM_1926.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV62596; ABV62596; BPUM_1926.
GeneID5621194.
KEGGbpu:BPUM_1926.
PATRIC18967748. VBIBacPum16546_1970.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycBPUM315750:GH6N-1982-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_BACP2
AccessionPrimary (citable) accession number: A8FEC9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways