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A8FEC9

- FTHS_BACP2

UniProt

A8FEC9 - FTHS_BACP2

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPUM315750:GH6N-1982-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BPUM_1926
OrganismiBacillus pumilus (strain SAFR-032)
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001355: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Formate--tetrahydrofolate ligasePRO_0000318564Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315750.BPUM_1926.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8FEC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITKHLSDID IAQQAKLRPI QDIAAKLQLH DEELECYGFT KAKISLTIFD
60 70 80 90 100
RLKEQKEGHV ILVTSINPTP AGEGKSTVTV GLGQAFEKIG KKAIIAMREP
110 120 130 140 150
SLGPTMGIKG GAAGGGYSQV LPMEEINLHF TGDFHAITSA HNALSAFIDN
160 170 180 190 200
HIHHGNELDI DARRIVWKRV LDLNDRALRQ VVVGLGGQVN GYPREDGFDI
210 220 230 240 250
TVASEMMAIL CLAEDLTDLK KRLSSIVVAY NRDGEPVTVG ALGYEGVLTL
260 270 280 290 300
LLKDALKPNL VQTIEGTPAL VHGGPFANIA HGCNSLIATK MAAKLADYVV
310 320 330 340 350
TEAGFGADLG AEKFLNIKTR AGDFKPGAVV IVATVRALKM HGGMKKTELK
360 370 380 390 400
EENTQAVLKG IHNLEKHIET VQAFGLPYIV AVNRFITDTK EEIQAIEDWC
410 420 430 440 450
LAHDHPVKAV NVWEEGGEGG TALAEELTTL IEKKKNSFSY LYEEDDSIEE
460 470 480 490 500
KLSKVAKVVY GADGVTLTSK ARKQLAAIEE NSWGHLPVCM AKTQYSLSDD
510 520 530 540 550
PALIGRPKGF TITIRELKPS VGAGFIVALT GSILTMPGLP KKPAALEMDL
560
LEDGSVTGLF
Length:560
Mass (Da):60,467
Last modified:November 13, 2007 - v1
Checksum:i06EBAA5FB9E818FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000813 Genomic DNA. Translation: ABV62596.1.
RefSeqiWP_012010314.1. NC_009848.1.
YP_001487156.1. NC_009848.1.

Genome annotation databases

EnsemblBacteriaiABV62596; ABV62596; BPUM_1926.
GeneIDi5621194.
KEGGibpu:BPUM_1926.
PATRICi18967748. VBIBacPum16546_1970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000813 Genomic DNA. Translation: ABV62596.1 .
RefSeqi WP_012010314.1. NC_009848.1.
YP_001487156.1. NC_009848.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315750.BPUM_1926.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV62596 ; ABV62596 ; BPUM_1926 .
GeneIDi 5621194.
KEGGi bpu:BPUM_1926.
PATRICi 18967748. VBIBacPum16546_1970.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BPUM315750:GH6N-1982-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAFR-032.

Entry informationi

Entry nameiFTHS_BACP2
AccessioniPrimary (citable) accession number: A8FEC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3