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A8FEA4 (MSRA_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase
Gene names
Name:msrA
Ordered Locus Names:BPUM_1901
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionpeptide-methionine-(S)-S-oxide reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401
PRO_1000068311

Sites

Active site141 By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FEA4 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 3C6D2237007A05C1

FASTA17820,507
        10         20         30         40         50         60 
MSEKQELATF AGGCFWCMVK PFDEQPGIIK VESGYTGGHT VNPTYEEVCT NTTGHREAVQ 

        70         80         90        100        110        120 
ITFDPDIFPY EKLLELYWQQ IDPTDDGGQF GDRGESYRTG IYVHHDEQRK LAEASKEKLN 

       130        140        150        160        170 
ESGIFQKPIV TEILDAAPFY PAEEYHQHYY KKNKIHYERY HVGSGRAGFI ESHWSDKS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV62571.1.
RefSeqYP_001487131.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FEA4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8FEA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000063412; EBBACP00000061745; EBBACG00000063403.
GeneID5621169.
GenomeReviewsGene locus BPUM_1901 in contig CP000813_GR.
KEGGbpu:BPUM_1901.
PATRIC18967698. VBIBacPum16546_1945.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0225.
GeneTreeEBGT00050000000580.
HOGENOMHBG748152.
OMAYEEVCTN.
ProtClustDBPRK14054.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_1901-MONOMER.

Family and domain databases

HAMAPMF_01401. MsrA.
[Tree]
InterProIPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
KOK07304.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
TIGRFAMsTIGR00401. MsrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRA_BACP2
AccessionPrimary (citable) accession number: A8FEA4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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