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A8FE66

- ODO1_BACP2

UniProt

A8FE66 - ODO1_BACP2

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene
odhA, BPUM_1862
Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBPUM315750:GH6N-1918-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:BPUM_1862
OrganismiBacillus pumilus (strain SAFR-032)
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001355: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9449442-oxoglutarate dehydrogenase E1 componentUniRule annotationPRO_1000065697Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi315750.BPUM_1862.

Structurei

3D structure databases

ProteinModelPortaliA8FE66.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQHAPNKE.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FE66-1 [UniParc]FASTAAdd to Basket

« Hide

MFQNDVKQPL SWEEFHGPNL GYVLELYDQY VQDPTSVDED LRGIFDELGA    50
PPSEMKEEIG KKENSVVTSE QIQKIASVVK LAEDIRTYGH LNASVNPLRK 100
EKELQELFPL KEYGLTEEDV KNIPISIISP DAPKHISNGI EAINHLRNTY 150
KRTISFEFDH VHDFEERNWL SKSIESGELF KKKPADKLVS VFKRLTEVEQ 200
FEQFLHKTFV GQKRFSIEGL DALVPVLDEI ISESVTQGTS NINIGMAHRG 250
RLNVLAHVLG KPYEIIFSEF QHAPNKELVP SEGSIGISYG WTGDVKYHLG 300
ADRQIKDEDT KSARVTLANN PSHLEFIDPI IEGSTRAAQE LRTQKGYPAQ 350
DVEKALAILI HGDAAFPGEG IVAETLNLSQ LVGYQVGGTI HIIANNMIGF 400
TTESNESRST KYASDLAKGF EIPIVHVNAD DPEACLAAVQ LAVEYRKRFK 450
KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD AVRKHKTVKN IFADKLVSEG 500
LLTKEQREEI EQAVATRIEE AYQKVPSKKE HTIQEIELPE PVSNGFPAVD 550
TSVEFDVLRK LNEELISWPD DFQVFGKLKR ILEKRAKVFT DDRKVEWSLG 600
EALAFASILK DGTPIRMTGQ DSERGTFAQR NLVLHDSQTG NEFIALHELS 650
DANASFTVHN SPLSEGSVIG FEYGYNVYSP ETLVIWEAQF GDFANAAQVY 700
FDQFISAGRA KWGQKSGLVM LLPHGYEGQG PEHSSGRTER FLQSAAENNW 750
TVANLTSAAQ YFHILRRQAK MLLREEIRPL VIMTPKSLLR NPNSLSEVQE 800
LTDGQFQPVL EQPGLVHDHE KVSRLVLSSG KVSIDISDRF TQMEEPKDWL 850
HIARVEQLYP FPAKDIKAIL SKLTNLEEIV WTQEEPQNMG AWGYIEPYLR 900
EIAPEKVKVR YIGRRRRSST AEGDPTVHKK EQERIVSDSL TRKN 944
Length:944
Mass (Da):106,822
Last modified:November 13, 2007 - v1
Checksum:i5CF1400B2F45876F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV62533.1.
RefSeqiWP_012010256.1. NC_009848.1.
YP_001487093.1. NC_009848.1.

Genome annotation databases

EnsemblBacteriaiABV62533; ABV62533; BPUM_1862.
GeneIDi5621130.
KEGGibpu:BPUM_1862.
PATRICi18967612. VBIBacPum16546_1902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV62533.1 .
RefSeqi WP_012010256.1. NC_009848.1.
YP_001487093.1. NC_009848.1.

3D structure databases

ProteinModelPortali A8FE66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315750.BPUM_1862.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV62533 ; ABV62533 ; BPUM_1862 .
GeneIDi 5621130.
KEGGi bpu:BPUM_1862.
PATRICi 18967612. VBIBacPum16546_1902.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi QHAPNKE.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci BPUM315750:GH6N-1918-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAFR-032.

Entry informationi

Entry nameiODO1_BACP2
AccessioniPrimary (citable) accession number: A8FE66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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