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A8FE66

- ODO1_BACP2

UniProt

A8FE66 - ODO1_BACP2

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotation

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciBPUM315750:GH6N-1918-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenaseUniRule annotation
    Gene namesi
    Name:odhAUniRule annotation
    Ordered Locus Names:BPUM_1862
    OrganismiBacillus pumilus (strain SAFR-032)
    Taxonomic identifieri315750 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001355: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9449442-oxoglutarate dehydrogenase E1 componentPRO_1000065697Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315750.BPUM_1862.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FE66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259588.
    KOiK00164.
    OMAiQHAPNKE.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8FE66-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQNDVKQPL SWEEFHGPNL GYVLELYDQY VQDPTSVDED LRGIFDELGA    50
    PPSEMKEEIG KKENSVVTSE QIQKIASVVK LAEDIRTYGH LNASVNPLRK 100
    EKELQELFPL KEYGLTEEDV KNIPISIISP DAPKHISNGI EAINHLRNTY 150
    KRTISFEFDH VHDFEERNWL SKSIESGELF KKKPADKLVS VFKRLTEVEQ 200
    FEQFLHKTFV GQKRFSIEGL DALVPVLDEI ISESVTQGTS NINIGMAHRG 250
    RLNVLAHVLG KPYEIIFSEF QHAPNKELVP SEGSIGISYG WTGDVKYHLG 300
    ADRQIKDEDT KSARVTLANN PSHLEFIDPI IEGSTRAAQE LRTQKGYPAQ 350
    DVEKALAILI HGDAAFPGEG IVAETLNLSQ LVGYQVGGTI HIIANNMIGF 400
    TTESNESRST KYASDLAKGF EIPIVHVNAD DPEACLAAVQ LAVEYRKRFK 450
    KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD AVRKHKTVKN IFADKLVSEG 500
    LLTKEQREEI EQAVATRIEE AYQKVPSKKE HTIQEIELPE PVSNGFPAVD 550
    TSVEFDVLRK LNEELISWPD DFQVFGKLKR ILEKRAKVFT DDRKVEWSLG 600
    EALAFASILK DGTPIRMTGQ DSERGTFAQR NLVLHDSQTG NEFIALHELS 650
    DANASFTVHN SPLSEGSVIG FEYGYNVYSP ETLVIWEAQF GDFANAAQVY 700
    FDQFISAGRA KWGQKSGLVM LLPHGYEGQG PEHSSGRTER FLQSAAENNW 750
    TVANLTSAAQ YFHILRRQAK MLLREEIRPL VIMTPKSLLR NPNSLSEVQE 800
    LTDGQFQPVL EQPGLVHDHE KVSRLVLSSG KVSIDISDRF TQMEEPKDWL 850
    HIARVEQLYP FPAKDIKAIL SKLTNLEEIV WTQEEPQNMG AWGYIEPYLR 900
    EIAPEKVKVR YIGRRRRSST AEGDPTVHKK EQERIVSDSL TRKN 944
    Length:944
    Mass (Da):106,822
    Last modified:November 13, 2007 - v1
    Checksum:i5CF1400B2F45876F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000813 Genomic DNA. Translation: ABV62533.1.
    RefSeqiWP_012010256.1. NC_009848.1.
    YP_001487093.1. NC_009848.1.

    Genome annotation databases

    EnsemblBacteriaiABV62533; ABV62533; BPUM_1862.
    GeneIDi5621130.
    KEGGibpu:BPUM_1862.
    PATRICi18967612. VBIBacPum16546_1902.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000813 Genomic DNA. Translation: ABV62533.1 .
    RefSeqi WP_012010256.1. NC_009848.1.
    YP_001487093.1. NC_009848.1.

    3D structure databases

    ProteinModelPortali A8FE66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315750.BPUM_1862.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV62533 ; ABV62533 ; BPUM_1862 .
    GeneIDi 5621130.
    KEGGi bpu:BPUM_1862.
    PATRICi 18967612. VBIBacPum16546_1902.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259588.
    KOi K00164.
    OMAi QHAPNKE.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci BPUM315750:GH6N-1918-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SAFR-032.

    Entry informationi

    Entry nameiODO1_BACP2
    AccessioniPrimary (citable) accession number: A8FE66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3