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A8FDV4 (IOLA_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylmalonate semialdehyde dehydrogenase [acylating]
Short name=MMSA dehydrogenase
Short name=MMSDH
Short name=MSDH
EC=1.2.1.27
Alternative name(s):
Malonate semialdehyde dehydrogenase [acetylating]
Short name=MSA dehydrogenase
EC=1.2.1.18
Gene names
Name:iolA
Ordered Locus Names:BPUM_1749
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity. HAMAP-Rule MF_01670

Catalytic activity

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP-Rule MF_01670

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP-Rule MF_01670

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP-Rule MF_01670

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Methylmalonate semialdehyde dehydrogenase [acylating] HAMAP-Rule MF_01670
PRO_0000352331

Regions

Nucleotide binding178 – 1825NAD By similarity

Sites

Active site2861Nucleophile By similarity
Binding site3861NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FDV4 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 418DF7891FAED79E

FASTA48653,208
        10         20         30         40         50         60 
MTKTDVQMLK NYIGGQWIEA ETSQTEAVYN PATGKIIAEV PLSTKKDVER AVQAAQEAFT 

        70         80         90        100        110        120 
TWSKTPVPRR ARILFKYQQL LVDKWDELAE LVTMENGKSI TEAKGEVQRG IECVEFAAGA 

       130        140        150        160        170        180 
PTLMMGKQLP DIASGLESGM YRYPIGVIGG ITPFNFPMMV PCWMFPLAIA CGNTFVLKPS 

       190        200        210        220        230        240 
ERTPILAARL AELFEEAGLP KGVLNIVNGA HDVVNGLLEH QKVKAISFVG SQPVAEYVYK 

       250        260        270        280        290        300 
KGTEHGKRVQ ALAGAKNHSI VLKDADLDAA TKQIIGAAFG SAGERCMAAA VVAVEEEVAD 

       310        320        330        340        350        360 
DLIQKLVDES NELVIGNGIN EEVFLGPVIR EEHKERTLQY IQSGIEEGAS LIRDGRKDHE 

       370        380        390        400        410        420 
TNGKGYFVGP TIFDHVTNQM KIWQDEIFAP VLSIVRVSSL AEAIDLSNQS KFANGACLYT 

       430        440        450        460        470        480 
DSASSIREFR ENIEAGMLGV NIGVPAPMAF FPFSGWKDSF YGDLHANGTD GVEFYTRKKM 


VTARYM

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV62421.1.
RefSeqYP_001486981.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FDV4.
SMRA8FDV4. Positions 5-485.
ModBaseSearch...

Protein-protein interaction databases

STRING315750.BPUM_1749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV62421; ABV62421; BPUM_1749.
GeneID5621016.
KEGGbpu:BPUM_1749.
PATRIC18967372. VBIBacPum16546_1782.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271507.
KOK00140.
OMARENIEAG.
ProtClustDBCLSK2485196.

Enzyme and pathway databases

BioCycBPUM315750:GH6N-1838-MONOMER.
UniPathwayUPA00076; UER00148.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_01670. IolA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
PANTHERPTHR11699:SF27. PTHR11699:SF27. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLA_BACP2
AccessionPrimary (citable) accession number: A8FDV4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 13, 2007
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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