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A8FDP7 (LEXA_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
LexA repressor

EC=3.4.21.88
Gene names
Name:lexA
Ordered Locus Names:BPUM_1686
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillus

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity. HAMAP MF_00015

Catalytic activity

Hydrolysis of Ala-|-Gly bond in repressor lexA. HAMAP MF_00015

Subunit structure

Homodimer By similarity. HAMAP MF_00015

Sequence similarities

Belongs to the peptidase S24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206LexA repressor HAMAP MF_00015
PRO_1000057126

Regions

DNA binding28 – 4821H-T-H motif By similarity

Sites

Active site1281For autocatalytic cleavage activity By similarity
Active site1661For autocatalytic cleavage activity By similarity
Site92 – 932Cleavage; by autolysis By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FDP7 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: BD44DE0A205EE5E5

FASTA20622,941
        10         20         30         40         50         60 
MTKLSKRQLD ILTFIKEEVK SKGYPPSVRE IGEAVGLASS STVHGHLARL ETKGLIRRDP 

        70         80         90        100        110        120 
TKPRAIEVLD EEELNIPKSA VMNVPVIGKV TAGLPITAVE NVEEYFPLPE TFAAPDEQVF 

       130        140        150        160        170        180 
MLEIMGESMI DAGILDKDYV IVRQQSTANN GDIVVAMTEE DEATVKRFYK EDTHFRLQPE 

       190        200 
NPSMEPIILQ NVSILGKVIG VFRNIH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000813 Genomic DNA. Translation: ABV62364.1.
RefSeqYP_001486924.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FDP7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8FDP7.

Protein family/group databases

MEROPSS24.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000065630; EBBACP00000063963; EBBACG00000065621.
GeneID5620953.
GenomeReviewsGene locus BPUM_1686 in contig CP000813_GR.
KEGGbpu:BPUM_1686.
PATRIC18967230. VBIBacPum16546_1711.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1974.
GeneTreeEBGT00050000002279.
HOGENOMHBG679610.
OMATIKRFFK.
ProtClustDBPRK00215.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_1686-MONOMER.

Family and domain databases

HAMAPMF_00015. LexA.
[Tree]
InterProIPR006199. LexA_DNA-bd_dom.
IPR006200. Pept_S24_LexA.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011056. Peptidase_S24_S26A/B/C_b-rbn.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:2.10.109.10. Pept_S24_S26_C. 1 hit.
G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KOK01356.
PfamPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00726. LEXASERPTASE.
SUPFAMSSF51306. Pept_S24_S26_C. 1 hit.
TIGRFAMsTIGR00498. LexA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLEXA_BACP2
AccessionPrimary (citable) accession number: A8FDP7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families