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A8FDB9 (DXR_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Short name=DXP reductoisomerase
EC=1.1.1.267
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene names
Name:dxr
Ordered Locus Names:BPUM_1554
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183

Cofactor

Divalent cation By similarity. HAMAP MF_00183

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183

Sequence similarities

Belongs to the DXR family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   LigandMetal-binding
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity

Inferred from electronic annotation. Source: EC

NADPH binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3833831-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
PRO_1000058412

Regions

Nucleotide binding7 – 3630NADP By similarity

Sites

Metal binding1481Divalent metal cation By similarity
Metal binding1501Divalent metal cation By similarity
Metal binding2191Divalent metal cation By similarity
Binding site1231Substrate By similarity
Binding site1501Substrate By similarity
Binding site1741Substrate By similarity
Binding site1971Substrate By similarity
Binding site2191Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FDB9 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 29376611EC56F6A1

FASTA38342,750
        10         20         30         40         50         60 
MRYISLLGAT GSIGEQTLDV IRQHPDKFKL KAMTFGRNVD KAIPIIEQFQ PEFVGCLSEE 

        70         80         90        100        110        120 
AYHTLKGHSF EYDVKMAAGD EANIEAAIYD AVDVVVNALV GSVGLVPTLK AIEQKKTIAL 

       130        140        150        160        170        180 
ANKETLVTAG HIVKEYAKTY DVPLLPVDSE HSAIFQCLQG EQAKNIERLI VTASGGSFRD 

       190        200        210        220        230        240 
KKRTELEGVT VEEALNHPNW SMGAKITIDS ATMMNKGLEV IEAHWLFDIP YEQIDVLLHK 

       250        260        270        280        290        300 
ESIIHSMVEF HDKSVMAQLG TPDMRVPIQY ALTYPDRAPL PEAKSLNLWE IGQLNFQKAD 

       310        320        330        340        350        360 
FDRYRCLHFA YESGKIGGTM PAVLNAANEM AVDAFLKGKV TFLQIEELIE KALNRHHVIS 

       370        380 
TPSLQDIHEV DKETRDFVQS ILT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV62236.1.
RefSeqYP_001486796.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FDB9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8FDB9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000065629; EBBACP00000063962; EBBACG00000065620.
GeneID5620821.
GenomeReviewsGene locus BPUM_1554 in contig CP000813_GR.
KEGGbpu:BPUM_1554.
PATRIC18966946. VBIBacPum16546_1569.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0743.
GeneTreeEBGT00050000001768.
HOGENOMHBG430762.
OMAIHSMVEY.
ProtClustDBPRK05447.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_1554-MONOMER.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDXR_BACP2
AccessionPrimary (citable) accession number: A8FDB9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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