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Protein
Submitted name:

16S rRNA methyltransferase

Gene

BPUM_1473

Organism
Bacillus pumilus (strain SAFR-032)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.SAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(967) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S rRNA.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei283S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei310S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei329S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei382NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotationImported, RNA-bindingPROSITE-ProRule annotationSAAS annotation, Transferase
Biological processrRNA processingSAAS annotation
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
16S rRNA methyltransferaseImported
Gene namesi
Ordered Locus Names:BPUM_1473Imported
OrganismiBacillus pumilus (strain SAFR-032)Imported
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001355 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi315750.BPUM_1473.

Structurei

3D structure databases

ProteinModelPortaliA8FD39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 446SAM_MT_RSMB_NOPInterPro annotationAdd BLAST277

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CYJ. Bacteria.
COG0144. LUCA.
HOGENOMiHOG000037300.
KOiK03500.
OMAiHIGLYQL.
OrthoDBiPOG091H02E2.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS01153. NOL1_NOP2_SUN. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FD39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSNVREVA LDALIKLEQN QAYSNLLLQS VMKDKDLADQ DKPLLTELVY
60 70 80 90 100
GTLQNKLALD YMLAPFVKKP QKVAPWVMQL LRMSLYQMVY LEKIPDRAAI
110 120 130 140 150
HEAVELTKKR GHKGISSLVN GVLRSVQREG VPAFDDIKDP VKRLSIETSH
160 170 180 190 200
PLWLVQEWVQ SYGFEATESM CRIHLVPPKQ TLRVNRIKTD RAALKQKLLD
210 220 230 240 250
AGIETELGDL SEDALKLMKG SIVSTPSFQE GYVTIQDESS MLVARALDPQ
260 270 280 290 300
PGETVLDACA APGGKSTHIA ERMNDEGQIV SLDLHEHKVK LIKQAAKRLN
310 320 330 340 350
LTQIEAKALD ARKAKDDYSE ASFDRILIDA PCSGFGVIRR KPDMKYTKSP
360 370 380 390 400
EDSARLAIIQ QAILKETAPL LKPGGTLVYS TCTMDPSENQ QVIHAFLQEH
410 420 430 440
QDFEPDLSLN ERLPEQVAPF VQNGSVQILP HYFGTDGFFI CSMRKKG
Length:447
Mass (Da):50,071
Last modified:November 13, 2007 - v1
Checksum:i36279B2E9A5430AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000813 Genomic DNA. Translation: ABV62156.1.
RefSeqiWP_012009916.1. NC_009848.4.

Genome annotation databases

KEGGibpu:BPUM_1473.
PATRICi18966783. VBIBacPum16546_1488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000813 Genomic DNA. Translation: ABV62156.1.
RefSeqiWP_012009916.1. NC_009848.4.

3D structure databases

ProteinModelPortaliA8FD39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315750.BPUM_1473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGibpu:BPUM_1473.
PATRICi18966783. VBIBacPum16546_1488.

Phylogenomic databases

eggNOGiENOG4105CYJ. Bacteria.
COG0144. LUCA.
HOGENOMiHOG000037300.
KOiK03500.
OMAiHIGLYQL.
OrthoDBiPOG091H02E2.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS01153. NOL1_NOP2_SUN. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA8FD39_BACP2
AccessioniPrimary (citable) accession number: A8FD39
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: February 15, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.