A8FD21 (PYRE_BACP2) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 30.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Orotate phosphoribosyltransferase Short name=OPRT Short name=OPRTase EC=2.4.2.10 | ||||
| Gene names |
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| Organism | Bacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 315750 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 212 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 |
| Catalytic activity | Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 |
| Cofactor | Magnesium By similarity. HAMAP MF_01208 |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 |
| Subunit structure | Homodimer By similarity. HAMAP MF_01208 |
| Sequence similarities | Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Ligand | Magnesium |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | orotate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 212 | 212 | Orotate phosphoribosyltransferase HAMAP MF_01208 | PRO_1000066204 | |||||
Regions | |||||||||
| Region | 120 – 128 | 9 | 5-phosphoribose 1-diphosphate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 94 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 98 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 100 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 124 | 1 | Orotate By similarity | ||||||
Sequences
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References
| [1] | "Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032." Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C. Weinstock G.M.PLoS ONE 2:E928-E928(2007) [PubMed: 17895969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SAFR-032. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000813 Genomic DNA. Translation: ABV62138.1. |
| RefSeq | YP_001486698.1. NC_009848.1. |
3D structure databases | |
| ProteinModelPortal | A8FD21. |
| SMR | A8FD21. Positions 1-204. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A8FD21. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000065163; EBBACP00000063496; EBBACG00000065154. |
| GeneID | 5620722. |
| GenomeReviews | Gene locus BPUM_1455 in contig CP000813_GR. |
| KEGG | bpu:BPUM_1455. |
| PATRIC | 18966747. VBIBacPum16546_1470. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0461. |
| GeneTree | EBGT00050000002725. |
| HOGENOM | HBG404341. |
| OMA | LPMTYVR. |
| ProtClustDB | PRK00455. |
Enzyme and pathway databases | |
| BioCyc | BPUM315750:BPUM_1455-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01208. PyrE. [Tree] |
| InterPro | IPR004467. Or_phspho_trans_clade-1. IPR023031. Orotate_PribosylTferase. IPR000836. PRibTrfase. [Graphical view] |
| KO | K00762. |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00336. PyrE. 1 hit. |
| PROSITE | PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRE_BACP2 | ||||||||
| Accession | Primary (citable) accession number: A8FD21 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with