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Reviewed, UniProtKB/Swiss-Prot A8FD21 (PYRE_BACP2)

Last modified November 3, 2009. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Orotate phosphoribosyltransferase
      Short name=OPRT
      Short name=OPRTase
    EC=2.4.2.10
Gene names
Name: pyrE
Ordered Locus Names: BPUM_1455
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity.

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_1000066204

Regions

Region120 – 12895-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site9415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site9815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1241Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FD21-1 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: AAE5D871E3314695

FASTA21222,931
        10         20         30         40         50         60 
MKTKIAKHLL QIKAVSLKPD EPFTWASGIK SPIYCDNRLT LSYPEVRHDI AEGLKELILT 

        70         80         90        100        110        120 
HFEGAEVIAG TATAGIPHAA LAADRLNAPM CYVRSKPKAH GKGNQIEGAV SKGQKVVVVE 

       130        140        150        160        170        180 
DLISTGGSVL EVVAALQEAG CDVLGVAAIF TYGLPKATAA FQEKNIPYVT LTDYDTLTDV 

       190        200        210 
ALELKAIEPS AMNKLKRWRQ DPSSESWMEE TV 

« Hide

Cross-references

Sequence databases

CP000813 Genomic DNA. Translation: ABV62138.1.
RefSeqYP_001486698.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA8FD21.

Genome annotation databases

GeneID5620722.
GenomeReviewsGene locus BPUM_1455 in contig CP000813_GR.
KEGGbpu:BPUM_1455.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAHAAWVSD.

Family and domain databases

HAMAPMF_01208.
[Tree]
InterProIPR004467. Or_phspho_trans.
IPR002375. Pr/py_Pribosyl_transf_CS.
IPR000836. PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. pyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_BACP2
AccessionPrimary (citable) accession number: A8FD21
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: November 3, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents