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A8FD12

- PYRR_BACP2

UniProt

A8FD12 - PYRR_BACP2

Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
    Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-HAMAP
    2. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
    2. nucleoside metabolic process Source: InterPro
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation, Transcription termination

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciBPUM315750:GH6N-1501-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein PyrRUniRule annotation
    Including the following 2 domains:
    Pyrimidine operon regulatory proteinUniRule annotation
    Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
    Short name:
    UPRTaseUniRule annotation
    Gene namesi
    Name:pyrRUniRule annotation
    Ordered Locus Names:BPUM_1446
    OrganismiBacillus pumilus (strain SAFR-032)
    Taxonomic identifieri315750 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001355: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180Bifunctional protein PyrRPRO_1000066735Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer and homohexamer; in equilibrium.UniRule annotation

    Protein-protein interaction databases

    STRINGi315750.BPUM_1446.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FD12.
    SMRiA8FD12. Positions 4-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi101 – 11313PRPP-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2065.
    HOGENOMiHOG000245770.
    KOiK02825.
    OMAiLMDMGRP.
    OrthoDBiEOG61VZD8.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01219. PyrR.
    InterProiIPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023050. PyrR.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8FD12-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQKAVILDE QAIRRALTRI AHEMIERNKG MKDVILAGIK TRGIHLAKRL    50
    AERIEQIEGN PVIVGELDIT LYRDDLTKKT DNQDPLVKGA DIPADINDKT 100
    LIVVDDVLFT GRTVRAAMDA LVDVGRPSSI QLAVLVDRGH RELPIRADYI 150
    GKNIPTSKAE TVMVQLNEVD QNDLVAIYEK 180
    Length:180
    Mass (Da):20,085
    Last modified:November 13, 2007 - v1
    Checksum:iF80731C59ACC17E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000813 Genomic DNA. Translation: ABV62129.1.
    RefSeqiYP_001486689.1. NC_009848.1.

    Genome annotation databases

    EnsemblBacteriaiABV62129; ABV62129; BPUM_1446.
    GeneIDi5620713.
    KEGGibpu:BPUM_1446.
    PATRICi18966729. VBIBacPum16546_1461.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000813 Genomic DNA. Translation: ABV62129.1 .
    RefSeqi YP_001486689.1. NC_009848.1.

    3D structure databases

    ProteinModelPortali A8FD12.
    SMRi A8FD12. Positions 4-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315750.BPUM_1446.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV62129 ; ABV62129 ; BPUM_1446 .
    GeneIDi 5620713.
    KEGGi bpu:BPUM_1446.
    PATRICi 18966729. VBIBacPum16546_1461.

    Phylogenomic databases

    eggNOGi COG2065.
    HOGENOMi HOG000245770.
    KOi K02825.
    OMAi LMDMGRP.
    OrthoDBi EOG61VZD8.

    Enzyme and pathway databases

    BioCyci BPUM315750:GH6N-1501-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01219. PyrR.
    InterProi IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023050. PyrR.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SAFR-032.

    Entry informationi

    Entry nameiPYRR_BACP2
    AccessioniPrimary (citable) accession number: A8FD12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3