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A8FD12

- PYRR_BACP2

UniProt

A8FD12 - PYRR_BACP2

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Protein
Bifunctional protein PyrR
Gene
pyrR, BPUM_1446
Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes By similarity.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant By similarity.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-HAMAP
  2. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. nucleoside metabolic process Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciBPUM315750:GH6N-1501-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrR
Including the following 2 domains:
Pyrimidine operon regulatory protein
Uracil phosphoribosyltransferase (EC:2.4.2.9)
Short name:
UPRTase
Gene namesi
Name:pyrR
Ordered Locus Names:BPUM_1446
OrganismiBacillus pumilus (strain SAFR-032)
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001355: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Bifunctional protein PyrRUniRule annotation
PRO_1000066735Add
BLAST

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium By similarity.

Protein-protein interaction databases

STRINGi315750.BPUM_1446.

Structurei

3D structure databases

ProteinModelPortaliA8FD12.
SMRiA8FD12. Positions 4-179.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi101 – 11313PRPP-binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2065.
HOGENOMiHOG000245770.
KOiK02825.
OMAiLMDMGRP.
OrthoDBiEOG61VZD8.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FD12-1 [UniParc]FASTAAdd to Basket

« Hide

MEQKAVILDE QAIRRALTRI AHEMIERNKG MKDVILAGIK TRGIHLAKRL    50
AERIEQIEGN PVIVGELDIT LYRDDLTKKT DNQDPLVKGA DIPADINDKT 100
LIVVDDVLFT GRTVRAAMDA LVDVGRPSSI QLAVLVDRGH RELPIRADYI 150
GKNIPTSKAE TVMVQLNEVD QNDLVAIYEK 180
Length:180
Mass (Da):20,085
Last modified:November 13, 2007 - v1
Checksum:iF80731C59ACC17E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV62129.1.
RefSeqiYP_001486689.1. NC_009848.1.

Genome annotation databases

EnsemblBacteriaiABV62129; ABV62129; BPUM_1446.
GeneIDi5620713.
KEGGibpu:BPUM_1446.
PATRICi18966729. VBIBacPum16546_1461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV62129.1 .
RefSeqi YP_001486689.1. NC_009848.1.

3D structure databases

ProteinModelPortali A8FD12.
SMRi A8FD12. Positions 4-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315750.BPUM_1446.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV62129 ; ABV62129 ; BPUM_1446 .
GeneIDi 5620713.
KEGGi bpu:BPUM_1446.
PATRICi 18966729. VBIBacPum16546_1461.

Phylogenomic databases

eggNOGi COG2065.
HOGENOMi HOG000245770.
KOi K02825.
OMAi LMDMGRP.
OrthoDBi EOG61VZD8.

Enzyme and pathway databases

BioCyci BPUM315750:GH6N-1501-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01219. PyrR.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAFR-032.

Entry informationi

Entry nameiPYRR_BACP2
AccessioniPrimary (citable) accession number: A8FD12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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