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A8FD12 (PYRR_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein PyrR

Including the following 2 domains:

  1. Pyrimidine operon regulatory protein
  2. Uracil phosphoribosyltransferase
    Short name=UPRTase
    EC=2.4.2.9
Gene names
Name:pyrR
Ordered Locus Names:BPUM_1446
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes By similarity. HAMAP-Rule MF_01219

Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant By similarity. HAMAP-Rule MF_01219

Catalytic activity

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01219

Subunit structure

Homodimer and homohexamer; in equilibrium By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180Bifunctional protein PyrR HAMAP-Rule MF_01219
PRO_1000066735

Regions

Motif101 – 11313PRPP-binding By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FD12 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: F80731C59ACC17E2

FASTA18020,085
        10         20         30         40         50         60 
MEQKAVILDE QAIRRALTRI AHEMIERNKG MKDVILAGIK TRGIHLAKRL AERIEQIEGN 

        70         80         90        100        110        120 
PVIVGELDIT LYRDDLTKKT DNQDPLVKGA DIPADINDKT LIVVDDVLFT GRTVRAAMDA 

       130        140        150        160        170        180 
LVDVGRPSSI QLAVLVDRGH RELPIRADYI GKNIPTSKAE TVMVQLNEVD QNDLVAIYEK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000813 Genomic DNA. Translation: ABV62129.1.
RefSeqYP_001486689.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FD12.
SMRA8FD12. Positions 4-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315750.BPUM_1446.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV62129; ABV62129; BPUM_1446.
GeneID5620713.
KEGGbpu:BPUM_1446.
PATRIC18966729. VBIBacPum16546_1461.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2065.
HOGENOMHOG000245770.
KOK02825.
OMALMDMGRP.
OrthoDBEOG61VZD8.

Enzyme and pathway databases

BioCycBPUM315750:GH6N-1501-MONOMER.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01219. PyrR.
InterProIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRR_BACP2
AccessionPrimary (citable) accession number: A8FD12
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families