Skip Header

Contribute Send feedback
Read comments (?) or add your own

A8FCY2 (MURB_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase
EC=1.1.1.158
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene names
Name:murB
Ordered Locus Names:BPUM_1416
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00037

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity. HAMAP MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm By similarity HAMAP MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_1000057272

Regions

Domain30 – 196167FAD-binding PCMH-type

Sites

Active site1741 By similarity
Active site2251Proton donor By similarity
Active site2951 By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FCY2 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: DF29FD0990A96454

FASTA30333,353
        10         20         30         40         50         60 
MENLKNELLE AQVGKVLENE PLANHTTMKI GGPADLLIIP KDIDAVKTIM DHVKKHQTNW 

        70         80         90        100        110        120 
TVIGRGSNLL VLDKGIRGVV LKLGTGLDHL TVNDEEITVG GGYSVVRLAT SLSKQGLSGL 

       130        140        150        160        170        180 
EFAAGIPGSI GGAVYMNAGA HGSDISKILV KARILFEDGS IEWLTNEQMN FSYRTSVLQK 

       190        200        210        220        230        240 
ERPGIVLEAV FKLKQDDREK ITKKMQQNKD YRKETQPYNR PCAGSIFRNP LPEYAGQLVE 

       250        260        270        280        290        300 
KANLKGYQLG GARISDMHGN FIVNAGGATA QDVLDLIQFI QKKIKEDYNV EMHTEVEIIG 


EEN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV62099.1.
RefSeqYP_001486659.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FCY2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8FCY2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000065134; EBBACP00000063467; EBBACG00000065125.
GeneID5620683.
GenomeReviewsGene locus BPUM_1416 in contig CP000813_GR.
KEGGbpu:BPUM_1416.
PATRIC18966667. VBIBacPum16546_1430.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0812.
GeneTreeEBGT00050000001391.
HOGENOMHBG686573.
OMAEANVGRV.
ProtClustDBPRK13905.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_1416-MONOMER.

Family and domain databases

HAMAPMF_00037. MurB.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
KOK00075.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. FAD-binding_2. 1 hit.
SSF56194. MurB_C. 1 hit.
TIGRFAMsTIGR00179. MurB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB_BACP2
AccessionPrimary (citable) accession number: A8FCY2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents