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A8FCX8 (MRAY_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BPUM_1412
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000057274

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane51 – 7121Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane227 – 24822Helical; Potential
Transmembrane253 – 27523Helical; Potential
Transmembrane302 – 32221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A8FCX8 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: F178AF58CAC91E7E

FASTA32435,542
        10         20         30         40         50         60 
MLEQVILFTI IMGFLISVLL SPIFIPFLRR LKFGQSIREE GPQSHQKKSG TPTMGGIMII 

        70         80         90        100        110        120 
FSITITTIVM INKFSEISPE MFLLLFVTLG YGLLGFLDDY IKVAMKRNLG LTSKQKLIGQ 

       130        140        150        160        170        180 
IVIAVIFYAV FHYYQFATTI RIPGTDVSFD LGWAYFILVV FMLVGGSNAV NLTDGLDGLL 

       190        200        210        220        230        240 
SGTAAIAFGA FAILAWNQSQ YDVAIFSVAV AGAVLGFLVF NAHPAKVFMG DTGSLALGGA 

       250        260        270        280        290        300 
IVAIAILTKL EILLVIIGGV FVVETLSVIL QVISFKTTGK RIFKMSPLHH HYELVGWSEW 

       310        320 
RVVVTFWTAG LLLAVLGIYI EVWL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV62095.1.
RefSeqYP_001486655.1. NC_009848.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA8FCX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000065355; EBBACP00000063688; EBBACG00000065346.
GeneID5620679.
GenomeReviewsGene locus BPUM_1412 in contig CP000813_GR.
KEGGbpu:BPUM_1412.
PATRIC18966659. VBIBacPum16546_1426.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
GeneTreeEBGT00050000001191.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_1412-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BACP2
AccessionPrimary (citable) accession number: A8FCX8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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