A8FCW1 (COAD_BACP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphopantetheine adenylyltransferase
EC=2.7.7.3

Alternative name(s):
Dephospho-CoA pyrophosphorylase
Pantetheine-phosphate adenylyltransferase
Short name=PPAT

Gene names

Name:	coaD
Ordered Locus Names:	BPUM_1395

Organism

Bacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]

Taxonomic identifier

315750 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP MF_00151
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity. HAMAP MF_00151
Subcellular location	Cytoplasm By similarity HAMAP MF_00151.
Sequence similarities	Belongs to the bacterial CoaD family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	Phosphopantetheine adenylyltransferase HAMAP MF_00151		PRO_1000058158

Sequences

	Sequence		Length	Mass (Da)
	A8FCW1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: BAB5EDFC3410F18F	FASTA	160	18,004
	10 20 30 40 50 60 MGNIAVCPGS FDPVTLGHLD IIKRGAKIFD EVYVCVLNNS SKKPLFTVEE RCELIRQATK 70 80 90 100 110 120 DLPNIKVESF HGLLVDYAKQ KEAKVILRGL RAVTDFEYEM QGTSMNKVLN DDIETFFMMT 130 140 150 160 NNQYSFLSSS IVKEVAKYDG SVKGLVPKEV EEALIEKFKG

References

[1]

"Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032." Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C. , Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K., Weinstock G.M. PLoS ONE 2:E928-E928(2007) [PubMed: 17895969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SAFR-032.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000813 Genomic DNA. Translation: ABV62078.1.
RefSeq	YP_001486638.1. NC_009848.1.
3D structure databases
ProteinModelPortal	A8FCW1.
SMR	A8FCW1. Positions 2-159.
ModBase	Search...
Protein-protein interaction databases
STRING	A8FCW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000064561; EBBACP00000062894; EBBACG00000064552.
GeneID	5620662.
GenomeReviews	Gene locus BPUM_1395 in contig CP000813_GR.
KEGG	bpu:BPUM_1395.
PATRIC	18966621. VBIBacPum16546_1407.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0669.
GeneTree	EBGT00050000002538.
HOGENOM	HBG288308.
OMA	AMSDFEY.
ProtClustDB	PRK00168.
Enzyme and pathway databases
BioCyc	BPUM315750:BPUM_1395-MONOMER.
Family and domain databases
HAMAP	MF_00151. PPAT_bact. [Tree]
InterPro	IPR004821. Cyt_trans-rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K00954.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
PRINTS	PR01020. LPSBIOSNTHSS.
TIGRFAMs	TIGR01510. CoaD_prev_kdtB. 1 hit. TIGR00125. Cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAD_BACP2

Accession

Primary (citable) accession number: A8FCW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program