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A8FBX4 (FABH_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.41
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:BPUM_1057
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm Probable HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Lipid synthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Multifunctional enzyme
Gene Ontology (GO)
   Biological processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-oxoacyl-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3123123-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_1000070214

Regions

Region238 – 2425ACP-binding By similarity

Sites

Active site1121 By similarity
Active site2371 By similarity
Active site2671 By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FBX4 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: CC1E73F56F656B56

FASTA31233,696
        10         20         30         40         50         60 
MNAGIIGLGR YIPEKVLTNL DLEKMVETSD EWIRTRTGIE ERRIASDDVN TSHMALAAAK 

        70         80         90        100        110        120 
KALADADVAA EDIDMILVAT VTPDQAFPTV ACMIQEQLGA HKACAMDISA ACAGFMYGLV 

       130        140        150        160        170        180 
TGKQFIESGT FKHVLVVGVE KLSRITDWDD RNTAVLFGDG AGAAVLGEVS EGKGILSFEL 

       190        200        210        220        230        240 
GADGRGGKHL YLDEKDHTIM NGREVFKFAV RQMGESSVNV IEKAGLSKED VDFLIPHQAN 

       250        260        270        280        290        300 
IRIMEAARER LELPVEKMSK TVHKYGNTSA ASIPISLCEE IEAGKIHDGD VIVMVGFGGG 

       310 
LTWGAIAMRW GR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV61741.1.
RefSeqYP_001486301.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FBX4.
SMRA8FBX4. Positions 1-311.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8FBX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000063427; EBBACP00000061760; EBBACG00000063418.
GeneID5620323.
GenomeReviewsGene locus BPUM_1057 in contig CP000813_GR.
KEGGbpu:BPUM_1057.
PATRIC18965949. VBIBacPum16546_1072.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
GeneTreeEBGT00050000001269.
HOGENOMHBG649927.
OMAKEIGAIN.
ProtClustDBPRK09352.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_1057-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABH_BACP2
AccessionPrimary (citable) accession number: A8FBX4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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