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A8FBM5 (DCUP_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:BPUM_0958
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325627

Regions

Region29 – 335Substrate binding By similarity

Sites

Binding site481Substrate By similarity
Binding site781Substrate By similarity
Binding site1541Substrate By similarity
Binding site2091Substrate By similarity
Binding site3221Substrate By similarity
Site781Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FBM5 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 519366CC2F2A720D

FASTA35239,754
        10         20         30         40         50         60 
MGKTKAFNDT FLKACKGEKT DHVPAWYMRQ AGRSQPEYRA LKEKYGLFEI THQPELCAYV 

        70         80         90        100        110        120 
TRLPVEQYGV DAAILYKDIM TPLPAIGVDV EIKNGIGPVI DSPIRTKADI ERLGELHPEE 

       130        140        150        160        170        180 
DLPYVLDTIQ LLTKEQLNVP LIGFAGAPFT MASYMIEGGP SKNYHKTKAL MYSEPETWML 

       190        200        210        220        230        240 
LMNKLADMTI TYIRAQVKAG VSAFQIFDSW VGALNAADYR TFIKPVMQRI FTELKSENVP 

       250        260        270        280        290        300 
MIMYGVGASH LVKDWHDLPL DVVGLDWRMS VDEARKEGLT KTLQGNLDPT ILLSPWEVIE 

       310        320        330        340        350 
ERAKDILDQG MKSDHFIFNL GHGVFPDVSP DTLKKLTDFI HDYSAKHKKS SI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV61642.1.
RefSeqYP_001486202.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8FBM5.
SMRA8FBM5. Positions 7-348.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8FBM5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000063968; EBBACP00000062301; EBBACG00000063959.
GeneID5620224.
GenomeReviewsGene locus BPUM_0958 in contig CP000813_GR.
KEGGbpu:BPUM_0958.
PATRIC18965741. VBIBacPum16546_0968.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
GeneTreeEBGT00050000000611.
HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_0958-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_BACP2
AccessionPrimary (citable) accession number: A8FBM5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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