Reviewed, UniProtKB/Swiss-Prot A8FB45 (FENR1_BACP2)

Names and origin

Protein names

Recommended name:
    Ferredoxin--NADP reductase 1
      Short name=Fd-NADP+ reductase 1
      Short name=FNR 1
    EC=1.18.1.2

Gene names

Ordered Locus Names:

BPUM_0777

Organism

Bacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]

Taxonomic identifier

315750 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP MF_01685
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_01685
Subunit structure	Homodimer By similarity. HAMAP MF_01685
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: HAMAP NADP or NADPH binding Inferred from electronic annotation. Source: HAMAP ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Ferredoxin--NADP reductase 1 HAMAP MF_01685		PRO_0000364799
Sites
	Binding site	37	1	FAD By similarity
	Binding site	45	1	FAD By similarity
	Binding site	49	1	FAD By similarity
	Binding site	89	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	124	1	FAD; via imide nitrogen By similarity
	Binding site	287	1	FAD By similarity
	Binding site	328	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8FB45-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 17D7846F74C57454	FASTA	346	38,418
	10 20 30 40 50 60 MTEQLELFDV TIIGGGPAGM YTAFYSGMRD LKTKVLEYNE SLGGKILLYP EKVIWDVGGL 70 80 90 100 110 120 PPTRGEQLIQ QLEKQAKTFE PEIALNQKIT SFERDEHQNI LLTAENGDRH LTKTLILAMG 130 140 150 160 170 180 HGIPVQRKLE IEHADRYEVT NLYYTVQELK TFAGKRVVIS GGGDSAVDWA NALVPIAESV 190 200 210 220 230 240 TVVHRRDMFG GHEKNVANMK ASCARILTPH ELTDLHGQGD KIDAVTIQHL ETGEIERIET 250 260 270 280 290 300 DAVIVNHGMK GDLSVLSEWG LKQGEWGLIE VNEKMETNLP GVYAVGDLCT HKSKVRLIAG 310 320 330 340 TFVDGVNALN SAKLYIEPEA EKVAYVSSHN ERFKEKNKEL QTVGAR

References

[1]

"Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032." Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C. , Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K., Weinstock G.M. PLoS ONE 2:E928-E928(2007) [PubMed: 17895969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000813 Genomic DNA. Translation: ABV61462.1.
RefSeq	YP_001486022.1.
3D structure databases
SMR	A8FB45. Positions 8-319.
ModBase	Search...
Protein-protein interaction databases
STRING	A8FB45.
Genome annotation databases
GeneID	5620023.
GenomeReviews	Gene locus BPUM_0777 in contig CP000813_GR.
KEGG	bpu:BPUM_0777.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0492.
HOGENOM	HBG669726.
OMA	AYVSSHN.
Family and domain databases
HAMAP	MF_01685. FENR2. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR001327. Pyr_OxRdtase_NAD_bd. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProtoNet	Search...

Entry information

Entry name

FENR1_BACP2

Accession

Primary (citable) accession number: A8FB45

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	November 13, 2007
Last modified:	January 19, 2010
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)