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A8FAM9

- PUR5_BACP2

UniProt

A8FAM9 - PUR5_BACP2

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, BPUM_0604
Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPUM315750:GH6N-642-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:BPUM_0604
OrganismiBacillus pumilus (strain SAFR-032)
Taxonomic identifieri315750 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001355: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000062156Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315750.BPUM_0604.

Structurei

3D structure databases

ProteinModelPortaliA8FAM9.
SMRiA8FAM9. Positions 13-340.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiPDMYGAD.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FAM9-1 [UniParc]FASTAAdd to Basket

« Hide

MSEAYKNAGV DIEAGYEAVK RMKTHVERTK RAGVMGALGG FGGMFDLSEL    50
PYKKPVLVSG TDGVGTKLKL AFLMDKHDTI GVDAVAMCVN DVLAQGAEPL 100
FFLDYLAVGK ADPVKIESIV KGVADGCEQS GSALVGGETA EMPGLYTEEE 150
YDIAGFSVGV VEKDEIVTGN SIKEGHLLIG LSSSGIHSNG YSLVRKVLLE 200
DAGLDLHQTY EPFKRPLGEE LLEPTKIYVK PVLKQVKAGK VDGMAHVTGG 250
GFIENLPRML PEGLGVEIDN GSWPVPPIFS FIQEKGQLKA EEMFNVFNMG 300
IGFVLAVKED DLVDVIRELE QDGEKAFLIG RVQKGEGVTF GGGSLS 346
Length:346
Mass (Da):37,015
Last modified:November 13, 2007 - v1
Checksum:iCA305C146277F768
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV61296.1.
RefSeqiYP_001485856.1. NC_009848.1.

Genome annotation databases

EnsemblBacteriaiABV61296; ABV61296; BPUM_0604.
GeneIDi5619852.
KEGGibpu:BPUM_0604.
PATRICi18964991. VBIBacPum16546_0613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000813 Genomic DNA. Translation: ABV61296.1 .
RefSeqi YP_001485856.1. NC_009848.1.

3D structure databases

ProteinModelPortali A8FAM9.
SMRi A8FAM9. Positions 13-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315750.BPUM_0604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV61296 ; ABV61296 ; BPUM_0604 .
GeneIDi 5619852.
KEGGi bpu:BPUM_0604.
PATRICi 18964991. VBIBacPum16546_0613.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi PDMYGAD.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci BPUM315750:GH6N-642-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAFR-032.

Entry informationi

Entry nameiPUR5_BACP2
AccessioniPrimary (citable) accession number: A8FAM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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