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A8FAM9

- PUR5_BACP2

UniProt

A8FAM9 - PUR5_BACP2

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bacillus pumilus (strain SAFR-032)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPUM315750:GH6N-642-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:BPUM_0604
    OrganismiBacillus pumilus (strain SAFR-032)
    Taxonomic identifieri315750 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001355: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000062156Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315750.BPUM_0604.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FAM9.
    SMRiA8FAM9. Positions 13-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiPDMYGAD.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8FAM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEAYKNAGV DIEAGYEAVK RMKTHVERTK RAGVMGALGG FGGMFDLSEL    50
    PYKKPVLVSG TDGVGTKLKL AFLMDKHDTI GVDAVAMCVN DVLAQGAEPL 100
    FFLDYLAVGK ADPVKIESIV KGVADGCEQS GSALVGGETA EMPGLYTEEE 150
    YDIAGFSVGV VEKDEIVTGN SIKEGHLLIG LSSSGIHSNG YSLVRKVLLE 200
    DAGLDLHQTY EPFKRPLGEE LLEPTKIYVK PVLKQVKAGK VDGMAHVTGG 250
    GFIENLPRML PEGLGVEIDN GSWPVPPIFS FIQEKGQLKA EEMFNVFNMG 300
    IGFVLAVKED DLVDVIRELE QDGEKAFLIG RVQKGEGVTF GGGSLS 346
    Length:346
    Mass (Da):37,015
    Last modified:November 13, 2007 - v1
    Checksum:iCA305C146277F768
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000813 Genomic DNA. Translation: ABV61296.1.
    RefSeqiYP_001485856.1. NC_009848.1.

    Genome annotation databases

    EnsemblBacteriaiABV61296; ABV61296; BPUM_0604.
    GeneIDi5619852.
    KEGGibpu:BPUM_0604.
    PATRICi18964991. VBIBacPum16546_0613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000813 Genomic DNA. Translation: ABV61296.1 .
    RefSeqi YP_001485856.1. NC_009848.1.

    3D structure databases

    ProteinModelPortali A8FAM9.
    SMRi A8FAM9. Positions 13-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315750.BPUM_0604.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV61296 ; ABV61296 ; BPUM_0604 .
    GeneIDi 5619852.
    KEGGi bpu:BPUM_0604.
    PATRICi 18964991. VBIBacPum16546_0613.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi PDMYGAD.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci BPUM315750:GH6N-642-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SAFR-032.

    Entry informationi

    Entry nameiPUR5_BACP2
    AccessioniPrimary (citable) accession number: A8FAM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3