ID   MTLD_BACP2              Reviewed;         373 AA.
AC   A8F9Z9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   16-JUN-2009, entry version 13.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase;
DE            EC=1.1.1.17;
GN   Name=mtlD; OrderedLocusNames=BPUM_0371;
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=315750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C.,
RA   Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C.,
RA   Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M.,
RA   Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P.,
RA   Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D.,
RA   Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E.,
RA   Venkateswaran K., Highlander S.K., Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
CC   -!- CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD(+) = D-fructose
CC       6-phosphate + NADH.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
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DR   EMBL; CP000813; ABV61066.1; -; Genomic_DNA.
DR   RefSeq; YP_001485626.1; -.
DR   GeneID; 5619598; -.
DR   GenomeReviews; CP000813_GR; BPUM_0371.
DR   KEGG; bpu:BPUM_0371; -.
DR   OMA; A8F9Z9; VDRIVPN.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00196; -; 1.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR000669; Mannitol_DH_core.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    373       Mannitol-1-phosphate 5-dehydrogenase.
FT                                /FTId=PRO_1000058530.
FT   NP_BIND       3     14       NAD (By similarity).
SQ   SEQUENCE   373 AA;  40725 MW;  E608556334BA19D4 CRC64;
     MKALHFGAGN IGRGFIGSLL KTSGFELVFT DVNEAVINEL NARGEYTVEL AAPGQKQEIV
     GPVTAINSAQ DPAALTEAVA SADLITTAVG PAVLKIIASS IAEGLKQKNP DHIINIVACE
     NMIGGSSHLK EAVFSHLTEE EQKALSQTVG FPNAAVDRIV PIQHHEDILK VSVEPFFEWV
     IDETGFIGDV PQIDGATFVQ DLTPYIERKL FTVNTGHALA AYVGYQQGVQ TIKEAVDTPE
     IRQVVEGALH ETGSYLIDTY GFKKEEHDAY IQKIIKRFEN VFISDEVTRV ARSPLRKLGA
     DDRLIGPAKK MKQPVYLIKG IAAALAYDFA EDEEAVRLQK LRKEKGIEGV LEEVCGLTPT
     DDLYQAILKE TTR
//