Reviewed, UniProtKB/Swiss-Prot A8F9Z9 (MTLD_BACP2)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	BPUM_0371

Organism

Bacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]

Taxonomic identifier

315750 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Mannitol-1-phosphate 5-dehydrogenase		PRO_1000058530
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8F9Z9-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: E608556334BA19D4	FASTA	373	40,725
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGSLL KTSGFELVFT DVNEAVINEL NARGEYTVEL AAPGQKQEIV 70 80 90 100 110 120 GPVTAINSAQ DPAALTEAVA SADLITTAVG PAVLKIIASS IAEGLKQKNP DHIINIVACE 130 140 150 160 170 180 NMIGGSSHLK EAVFSHLTEE EQKALSQTVG FPNAAVDRIV PIQHHEDILK VSVEPFFEWV 190 200 210 220 230 240 IDETGFIGDV PQIDGATFVQ DLTPYIERKL FTVNTGHALA AYVGYQQGVQ TIKEAVDTPE 250 260 270 280 290 300 IRQVVEGALH ETGSYLIDTY GFKKEEHDAY IQKIIKRFEN VFISDEVTRV ARSPLRKLGA 310 320 330 340 350 360 DDRLIGPAKK MKQPVYLIKG IAAALAYDFA EDEEAVRLQK LRKEKGIEGV LEEVCGLTPT 370 DDLYQAILKE TTR

References

[1]

"Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032." Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C. , Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K., Weinstock G.M. PLoS ONE 2:E928-E928(2007) [PubMed: 17895969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000813 Genomic DNA. Translation: ABV61066.1.
RefSeq	YP_001485626.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5619598.
GenomeReviews	Gene locus BPUM_0371 in contig CP000813_GR.
KEGG	bpu:BPUM_0371.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_BACP2

Accession

Primary (citable) accession number: A8F9Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	November 25, 2008
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)