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A8F9T1 (ROCA_BACP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-pyrroline-5-carboxylate dehydrogenase
Short name=P5C dehydrogenase
EC=1.5.1.12
Gene names
Name:rocA
Ordered Locus Names:BPUM_0301
OrganismBacillus pumilus (strain SAFR-032) [Complete proteome] [HAMAP]
Taxonomic identifier315750 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H. HAMAP MF_00733

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP MF_00733

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RocA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5155151-pyrroline-5-carboxylate dehydrogenase HAMAP MF_00733
PRO_1000062115

Sites

Active site2861 By similarity
Active site3201 By similarity

Sequences

Sequence LengthMass (Da)Tools
A8F9T1 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 4A3A6EB3092CC041

FASTA51556,373
        10         20         30         40         50         60 
MTTPYKHEPF TDFSQEENRK AFEQALGKVT ETLGQTYPLV INGERIETKD QIVSINPAKK 

        70         80         90        100        110        120 
DEVVGTVSKA GKEEAEQAVQ AAAKAFETWR YTSPEERASV IFRAAANIRR KKHEYSALLV 

       130        140        150        160        170        180 
KEAGKPWNEA DADTAEAIDF LEYYARQMLE LAKGKPVNSR EGEHNQYVYT PTGVTLVIPP 

       190        200        210        220        230        240 
WNFLFAIMAG TTVAPIVTGN TVVLKPASAT PVIAARFVEE LEQAGLPKGV VNFVPGSGAE 

       250        260        270        280        290        300 
VGDYLVDHPK TSLITFTGSR EVGTRIFERA AKVQPGQQHL KRVIAEMGGK DTVVVDEDAD 

       310        320        330        340        350        360 
VELAANAIFT SAFGFSGQKC SAGSRAVVHE KLYDQVIERV KEITETKTTA NPLSADVYMG 

       370        380        390        400        410        420 
PVIDQASFDK ITDYIEVGKQ EGRLVTGGTS DDTEGYFIHP TVFADLEPTS RLMQEEIFGP 

       430        440        450        460        470        480 
VLAFSKVSSF DEALEVANNT EYGLTGAVIT NNRDHINRAK QEFHVGNLYF NRNCTGAIVG 

       490        500        510 
YHPFGGFKMS GTDSKAGGPD YLALHMQAKT ISEMF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000813 Genomic DNA. Translation: ABV60998.1.
RefSeqYP_001485558.1. NC_009848.1.

3D structure databases

ProteinModelPortalA8F9T1.
SMRA8F9T1. Positions 3-515.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8F9T1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000064954; EBBACP00000063287; EBBACG00000064945.
GeneID5619528.
GenomeReviewsGene locus BPUM_0301 in contig CP000813_GR.
KEGGbpu:BPUM_0301.
PATRIC18964341. VBIBacPum16546_0306.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
GeneTreeEBGT00070000031871.
HOGENOMHBG752218.
OMATPYKHEP.
ProtClustDBPRK03137.

Enzyme and pathway databases

BioCycBPUM315750:BPUM_0301-MONOMER.

Family and domain databases

HAMAPMF_00733. RocA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. Delta1-pyrroline-5-COlate_DH-2.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00294.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameROCA_BACP2
AccessionPrimary (citable) accession number: A8F9T1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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