A8F8M9 (GCST_THELT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Tlet_1959

Organism

Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO) [Complete proteome] [HAMAP]

Taxonomic identifier

416591 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Aminomethyltransferase HAMAP MF_00259		PRO_1000059090

Sequences

	Sequence		Length	Mass (Da)
	A8F8M9 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 1D6D446298BF860C	FASTA	362	40,973
	10 20 30 40 50 60 MRRTPLYESH VSLGAKMIDF AGWEMPLQYT SINDEVATVR KNVALFDVSH MGEIFVEGED 70 80 90 100 110 120 TVEFVDYLLT NSFKNLRIGQ VMYTVMCNEM GGIIDDLLTY RFGEKQAMLV VNAANIEKDF 130 140 150 160 170 180 DWIVNQSKQF NVTVRNLSDQ YGLIAVQGPL SERFLKTFVS DIDSLSYYTF ASYSVFGKNC 190 200 210 220 230 240 IVSRTGYTGE DGFEIYCHWD DTFTVWNELL QRGNNFGVKP AGLGARDVCR LEASYMLYGN 250 260 270 280 290 300 DMDETTTPLE VGLSWVVKFD KDFIGKDSLI KQKELGLQKR IRGLEISDRR IARHGMYVFK 310 320 330 340 350 360 GEKRVGVVTS GTFSPTLEKP VALAMLSSEI KISDEIEVDI RGSKVKAMIV KLPFYRGSVK SS

References

[1]

"Complete sequence of Thermotoga lettingae TMO." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Bruce D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-301 / DSM 14385 / TMO.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000812 Genomic DNA. Translation: ABV34513.1.
RefSeq	YP_001471577.1. NC_009828.1.
3D structure databases
ProteinModelPortal	A8F8M9.
SMR	A8F8M9. Positions 1-360.
ModBase	Search...
Protein-protein interaction databases
STRING	A8F8M9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5607642.
GenomeReviews	Gene locus Tlet_1959 in contig CP000812_GR.
KEGG	tle:Tlet_1959.
PATRIC	23934641. VBITheLet125395_2049.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	VINASNK.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	TLET416591:TLET_1959-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_THELT

Accession

Primary (citable) accession number: A8F8M9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program