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A8F8M6

- GCSPB_THELT

UniProt

A8F8M6 - GCSPB_THELT

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTLET416591:GI64-2009-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Tlet_1956
OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000002016: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000062081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi416591.Tlet_1956.

Structurei

3D structure databases

ProteinModelPortaliA8F8M6.
SMRiA8F8M6. Positions 2-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A8F8M6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIFEKSVPG RKAYRLPDEE LQRIDPVFPE HLKRTRPLRL PELSEPDVVR
60 70 80 90 100
HYTALAEKNY SVDKGFYPLG SCTMKYNPKL NEYVAGLEGF TDIHPYQPWE
110 120 130 140 150
SVQGALQVMY ELKEFLCEIT GMDEMTLQPA AGAHGELTGM LIVRAYHLSR
160 170 180 190 200
NDKKRHVALV PDSAHGTNPA SAAMAGFDVV EIKSTEDGLV DLEQLENHLN
210 220 230 240 250
DEIAVLMLTN PNTLGLFEKD IVKIAEKVHQ AGALLYYDGA NLNAIMGKIK
260 270 280 290 300
PGEMGFDIVH LNLHKTFSAP HGMGGPGSGP VGVKAFLSEF LPIPIIRKDG
310 320 330 340 350
DKYYPDFKLP NSIGRTRSFY GNFLVLLKAY VYILSMGKDG LTRASEMAVL
360 370 380 390 400
NANYLRSLIS KFLKIASPGI CMHEFVVDGS QFVKETGVKI LDVAKRILDY
410 420 430 440 450
GLHAPTVYFP LIVHEDMMIE PTETENKNTL DYFAKVLEKI VEEAKKTPEV
460 470
VKTAPHTTPV KRLDDITATK KPVYRYRLS
Length:479
Mass (Da):53,612
Last modified:November 13, 2007 - v1
Checksum:i0E9F5B51925C8736
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34510.1.
RefSeqiYP_001471574.1. NC_009828.1.

Genome annotation databases

EnsemblBacteriaiABV34510; ABV34510; Tlet_1956.
GeneIDi5608229.
KEGGitle:Tlet_1956.
PATRICi23934635. VBITheLet125395_2046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34510.1 .
RefSeqi YP_001471574.1. NC_009828.1.

3D structure databases

ProteinModelPortali A8F8M6.
SMRi A8F8M6. Positions 2-477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416591.Tlet_1956.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV34510 ; ABV34510 ; Tlet_1956 .
GeneIDi 5608229.
KEGGi tle:Tlet_1956.
PATRICi 23934635. VBITheLet125395_2046.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci TLET416591:GI64-2009-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-301 / DSM 14385 / TMO.

Entry informationi

Entry nameiGCSPB_THELT
AccessioniPrimary (citable) accession number: A8F8M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3