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A8F8I1

- PUR5_THELT

UniProt

A8F8I1 - PUR5_THELT

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTLET416591:GI64-1958-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Tlet_1911
OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000002016: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000148306Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416591.Tlet_1911.

Structurei

3D structure databases

ProteinModelPortaliA8F8I1.
SMRiA8F8I1. Positions 14-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A8F8I1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFTYKDSGV DIDAADLSVQ MIKRYARQTH IDGVLGDIGN FGAFFQLDGS
60 70 80 90 100
LRQPVLVSGA DGVGTKLKVA FMMDKHDTVG IDCVAMCVND ILVHGARPLF
110 120 130 140 150
FLDYIAVGKL IPEKISQIVK GIAEGCTQAG CALIGGETAQ MPDMYKEEEY
160 170 180 190 200
DLAGFAVGVV EREKLLDGSK IKQRDAVIGL ASSGLHSNGF SLVRKVLLGK
210 220 230 240 250
MKVDEYISDL KKTLGEELLT PTKIYVRTVL DVLNDKIHGM AHITGGGLLE
260 270 280 290 300
NLPRILPEGL EFRIDKNSWE VPVIFKIIQR LGKIDSKEMY RTFNMGIGFV
310 320 330
MVVERDEVEN LLRKLNELGQ NAWVIGDIVP GEKGVII
Length:337
Mass (Da):36,973
Last modified:November 13, 2007 - v1
Checksum:i2A1CB756EC4BC2A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34465.1.
RefSeqiWP_012003941.1. NC_009828.1.
YP_001471529.1. NC_009828.1.

Genome annotation databases

EnsemblBacteriaiABV34465; ABV34465; Tlet_1911.
GeneIDi5607723.
KEGGitle:Tlet_1911.
PATRICi23934535. VBITheLet125395_2000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34465.1 .
RefSeqi WP_012003941.1. NC_009828.1.
YP_001471529.1. NC_009828.1.

3D structure databases

ProteinModelPortali A8F8I1.
SMRi A8F8I1. Positions 14-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416591.Tlet_1911.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV34465 ; ABV34465 ; Tlet_1911 .
GeneIDi 5607723.
KEGGi tle:Tlet_1911.
PATRICi 23934535. VBITheLet125395_2000.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci TLET416591:GI64-1958-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-301 / DSM 14385 / TMO.

Entry informationi

Entry nameiPUR5_THELT
AccessioniPrimary (citable) accession number: A8F8I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3