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A8F8B7

- SYL_THELT

UniProt

A8F8B7 - SYL_THELT

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTLET416591:GI64-1892-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Tlet_1847
    OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
    Taxonomic identifieri416591 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000002016: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 815815Leucine--tRNA ligasePRO_1000071114Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi416591.Tlet_1847.

    Structurei

    3D structure databases

    ProteinModelPortaliA8F8B7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8F8B7-1 [UniParc]FASTAAdd to Basket

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    MPRYEPQEIE SKWQKFWEKE GLFKTPQHSD LPKYYMLVMF PYPSGTLHVG    50
    HVKNYVIGDA VARYKRMRAY NVLHPFGYDA FGLPAENAAI ERKIHPKDWT 100
    LNNINIIRRQ IKKLGISYDW NREVITCLES YYKWTEWIFL KLYEAGLAYK 150
    KKAAVNWCPK CMTSLANEQV KDGRCERCDT PVTIKHLEQW FFKITDYAER 200
    LLKDLDKLTG WPEHVKTMQR NWIGESKGAK ISFKVEESEM NIEVFTTRPD 250
    TLWGVTFMVL APESDLVNHI TLPELKGELE KFLNYVGQQD RHKRGSADVE 300
    KEGFFTGRYA INPVSGERIP IYVANYVLME YGTGAVMGVP AHDQRDYEFA 350
    VKYNLPIKEV IKPSEDIPKN RAYDGPGIMV NSGPLNGTVV PEGIERVIQW 400
    LEERGIAKRS VQYKLRDWLI SRQRYWGAPI PIVYCEKCGM VPVPEKSLPV 450
    QLPYDVEFLP TGQSPLMLND EFRKTSCPKC GGPALRDADT MDTFVDSSWY 500
    FLRYVNPDRD DVPFVKEDVD HWLPVDQYVG GVEHAVLHLL YSRFITKVLY 550
    DLGYLSFDEP FENLFTQGMI YKDGAKMSKS KGNVVSPDEM IDRYGADTLR 600
    MYILFMGPPE RDAEWNDAGI EGVYRFIRRA WSLMDQIISL PDNQNQVFAE 650
    EEKHLRRKLH ISLRKVTQDM EGGFKFNTVV SSLMELVNDA YDYIDNLPQH 700
    RWNIKLLKEL AKNFVLMISP FAPHFAEELW QRMGYSSSVM KEKWPEYDPD 750
    ALVVEEVEIA IQVNGKLRDK VKIPVDATED QIKEIALKSE KVRKYISDEP 800
    KKIIYVPKRL LNIIF 815
    Length:815
    Mass (Da):94,816
    Last modified:November 13, 2007 - v1
    Checksum:iFE81700E65574478
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000812 Genomic DNA. Translation: ABV34401.1.
    RefSeqiYP_001471465.1. NC_009828.1.

    Genome annotation databases

    EnsemblBacteriaiABV34401; ABV34401; Tlet_1847.
    GeneIDi5607865.
    KEGGitle:Tlet_1847.
    PATRICi23934397. VBITheLet125395_1933.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000812 Genomic DNA. Translation: ABV34401.1 .
    RefSeqi YP_001471465.1. NC_009828.1.

    3D structure databases

    ProteinModelPortali A8F8B7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416591.Tlet_1847.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV34401 ; ABV34401 ; Tlet_1847 .
    GeneIDi 5607865.
    KEGGi tle:Tlet_1847.
    PATRICi 23934397. VBITheLet125395_1933.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci TLET416591:GI64-1892-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-301 / DSM 14385 / TMO.

    Entry informationi

    Entry nameiSYL_THELT
    AccessioniPrimary (citable) accession number: A8F8B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3