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A8F7Q8

- GCH4_THELT

UniProt

A8F7Q8 - GCH4_THELT

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei145 – 1451May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciTLET416591:GI64-1678-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Tlet_1638
    OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
    Taxonomic identifieri416591 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000002016: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258GTP cyclohydrolase FolE2PRO_0000316534Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi416591.Tlet_1638.

    Structurei

    3D structure databases

    ProteinModelPortaliA8F7Q8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8F7Q8-1 [UniParc]FASTAAdd to Basket

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    MKDVQNQPDN RNIYLQRVGI RNLQYPVTVM DRNNGYQDTV ATINMYVDLP    50
    VNFRGTHMSR FVEVLNRYRL GIDPKIIKNM LEELRNNLNA SVARVEIEFP 100
    YFILKKAPVS SIESFLKYTC RIEGQKTEKL YEFTMSVGVP IMTLCPCSKE 150
    ISERGAHNQR AMAWIHIKSK KMIWFEELID AAEQAASSPV FTILKRVDEK 200
    FVTEHAYDNP RFVEDVAREI AVRLNRDERI SWYRVEVESF ESIHDHSAYA 250
    CVMKDKED 258
    Length:258
    Mass (Da):30,210
    Last modified:November 13, 2007 - v1
    Checksum:i1710C281F38810CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000812 Genomic DNA. Translation: ABV34192.1.
    RefSeqiYP_001471256.1. NC_009828.1.

    Genome annotation databases

    EnsemblBacteriaiABV34192; ABV34192; Tlet_1638.
    GeneIDi5608691.
    KEGGitle:Tlet_1638.
    PATRICi23933961. VBITheLet125395_1720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000812 Genomic DNA. Translation: ABV34192.1 .
    RefSeqi YP_001471256.1. NC_009828.1.

    3D structure databases

    ProteinModelPortali A8F7Q8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416591.Tlet_1638.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV34192 ; ABV34192 ; Tlet_1638 .
    GeneIDi 5608691.
    KEGGi tle:Tlet_1638.
    PATRICi 23933961. VBITheLet125395_1720.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci TLET416591:GI64-1678-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-301 / DSM 14385 / TMO.

    Entry informationi

    Entry nameiGCH4_THELT
    AccessioniPrimary (citable) accession number: A8F7Q8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3