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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO) (Thermotoga lettingae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei145May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciTLET416591:G1G9T-1693-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Tlet_1638
OrganismiPseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO) (Thermotoga lettingae)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePseudothermotoga
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003165341 – 258GTP cyclohydrolase FolE2Add BLAST258

Interactioni

Protein-protein interaction databases

STRINGi416591.Tlet_1638

Structurei

3D structure databases

ProteinModelPortaliA8F7Q8
SMRiA8F7Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

A8F7Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVQNQPDN RNIYLQRVGI RNLQYPVTVM DRNNGYQDTV ATINMYVDLP
60 70 80 90 100
VNFRGTHMSR FVEVLNRYRL GIDPKIIKNM LEELRNNLNA SVARVEIEFP
110 120 130 140 150
YFILKKAPVS SIESFLKYTC RIEGQKTEKL YEFTMSVGVP IMTLCPCSKE
160 170 180 190 200
ISERGAHNQR AMAWIHIKSK KMIWFEELID AAEQAASSPV FTILKRVDEK
210 220 230 240 250
FVTEHAYDNP RFVEDVAREI AVRLNRDERI SWYRVEVESF ESIHDHSAYA

CVMKDKED
Length:258
Mass (Da):30,210
Last modified:November 13, 2007 - v1
Checksum:i1710C281F38810CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000812 Genomic DNA Translation: ABV34192.1
RefSeqiWP_012003668.1, NC_009828.1

Genome annotation databases

EnsemblBacteriaiABV34192; ABV34192; Tlet_1638
KEGGitle:Tlet_1638

Entry informationi

Entry nameiGCH4_PSELT
AccessioniPrimary (citable) accession number: A8F7Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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