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A8F7Q8

- GCH4_THELT

UniProt

A8F7Q8 - GCH4_THELT

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei145 – 1451May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciTLET416591:GI64-1678-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Tlet_1638
OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000002016: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258GTP cyclohydrolase FolE2PRO_0000316534Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416591.Tlet_1638.

Structurei

3D structure databases

ProteinModelPortaliA8F7Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8F7Q8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDVQNQPDN RNIYLQRVGI RNLQYPVTVM DRNNGYQDTV ATINMYVDLP
60 70 80 90 100
VNFRGTHMSR FVEVLNRYRL GIDPKIIKNM LEELRNNLNA SVARVEIEFP
110 120 130 140 150
YFILKKAPVS SIESFLKYTC RIEGQKTEKL YEFTMSVGVP IMTLCPCSKE
160 170 180 190 200
ISERGAHNQR AMAWIHIKSK KMIWFEELID AAEQAASSPV FTILKRVDEK
210 220 230 240 250
FVTEHAYDNP RFVEDVAREI AVRLNRDERI SWYRVEVESF ESIHDHSAYA

CVMKDKED
Length:258
Mass (Da):30,210
Last modified:November 13, 2007 - v1
Checksum:i1710C281F38810CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34192.1.
RefSeqiYP_001471256.1. NC_009828.1.

Genome annotation databases

EnsemblBacteriaiABV34192; ABV34192; Tlet_1638.
GeneIDi5608691.
KEGGitle:Tlet_1638.
PATRICi23933961. VBITheLet125395_1720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34192.1 .
RefSeqi YP_001471256.1. NC_009828.1.

3D structure databases

ProteinModelPortali A8F7Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416591.Tlet_1638.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV34192 ; ABV34192 ; Tlet_1638 .
GeneIDi 5608691.
KEGGi tle:Tlet_1638.
PATRICi 23933961. VBITheLet125395_1720.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci TLET416591:GI64-1678-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-301 / DSM 14385 / TMO.

Entry informationi

Entry nameiGCH4_THELT
AccessioniPrimary (citable) accession number: A8F7Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3