A8F7M5 (A8F7M5_THELT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thioredoxin reductase RuleBase RU003881
EC=1.8.1.9 RuleBase RU003881

Gene names

Ordered Locus Names:

Tlet_1605

Organism

Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO) [Complete proteome] [HAMAP]

Taxonomic identifier

416591 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH. RuleBase RU003881
Cofactor	Binds 1 FAD per subunit By similarity. RuleBase RU003881
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. RuleBase RU003880

Ontologies

Keywords
Domain	Redox-active center RuleBase RU003880
Ligand	FAD RuleBase RU003880 Flavoprotein RuleBase RU003880
Molecular function	Oxidoreductase RuleBase RU003880
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8F7M5 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: DBE17F5FB0B4FCB0	FASTA	313	34,782
	10 20 30 40 50 60 MFFEVGSTKS IKDYYDIVTI GGGPAALSAA VYAKRAGLSV LVVEKVLEGG QLNLTTYIDN 70 80 90 100 110 120 YLGFPNIEGQ ELARKMKEHA ESLQTEFLNN HVIELNVENS EMIIKTEERI VKSRVVMIAT 130 140 150 160 170 180 GADPKKLEVP GEREFLAKGI SYCATCDGYF FKDKDVAVIG GGDTALNDAL YLSKIAKSVT 190 200 210 220 230 240 VIHRRDKLRA VKILQDKAFS NGKIKFAFDN VVERFHGDKK LERIVLRNVK TGQISELKVD 250 260 270 280 290 300 GVFIAIGLKP NSELVKDIVK IDEQGYIFTD EWMQTNIPRL YAIGDVRKKN VRQIITAVSD 310 GAIAAIHAAE NYF

References

[1]

"Complete sequence of Thermotoga lettingae TMO." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Bruce D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-301 / DSM 14385 / TMO.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000812 Genomic DNA. Translation: ABV34159.1.
RefSeq	YP_001471223.1. NC_009828.1.
3D structure databases
ProteinModelPortal	A8F7M5.
ModBase	Search...
Protein-protein interaction databases
STRING	A8F7M5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5608605.
GenomeReviews	Gene locus Tlet_1605 in contig CP000812_GR.
KEGG	tle:Tlet_1605.
PATRIC	23933895. VBITheLet125395_1687.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG669726.
OMA	RMETKIP.
Enzyme and pathway databases
BioCyc	TLET416591:TLET_1605-MONOMER.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8F7M5_THELT

Accession

Primary (citable) accession number: A8F7M5

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)