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A8F7D5 (FTHS_THELT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Tlet_1513
OrganismThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO) [Complete proteome] [HAMAP]
Taxonomic identifier416591 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000068797

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8F7D5 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 4A5F59E26DF224C2

FASTA55359,366
        10         20         30         40         50         60 
MLSDIEIARS AKLEPVMNIA KNLSIPGDFL NSYGKFMAKI SHSFLKNLNI RKGKLILVTA 

        70         80         90        100        110        120 
MTPTPAGEGK TTTSIGLSMA LNKIGHRSIV TLREPSLGPV FGIKGGAAGG GYSQVLPMED 

       130        140        150        160        170        180 
INLHFTGDIH AVGTAHNLIS AVIDSHIRFG NDLDIDLTKI TWPRAIDMND RALRNIVIAL 

       190        200        210        220        230        240 
GGHANGYPRE DGFVITAASE IMAILCLSKD LQDLKNRVGN IVIGWSKNGK PVTVHELGIE 

       250        260        270        280        290        300 
GAIAVILKDA INPNLVQTIE NTPAFIHGGP FANIAHGTNS IIATKMALGL SDYVVTESGF 

       310        320        330        340        350        360 
GSDLGAEKFF DFVSPAADLK PSVAVIVATV RAIKYHGGVP LKDLENENLE AIKKGIENLK 

       370        380        390        400        410        420 
IHIENVKKFN VPVVVALNRF ATDTERELDL VVNTVEKLGT KISLNEAFAK GSEGAIDLAK 

       430        440        450        460        470        480 
KVIEVADESK FSPIYKWDSP VEEKIKILAT EIYRAKDVSF SKEAITSLKQ IEKAGLSNLP 

       490        500        510        520        530        540 
VIVAKTQYSI SDDPSKLGAP DGYVFNVRNF KLSSGAGFIV AISGEIMLMP GLGKKPNAVN 

       550 
IDIDEKGNIT GLF 

« Hide

References

[1]"Complete sequence of Thermotoga lettingae TMO."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Bruce D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-301 / DSM 14385 / TMO.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000812 Genomic DNA. Translation: ABV34069.1.
RefSeqYP_001471133.1. NC_009828.1.

3D structure databases

ProteinModelPortalA8F7D5.
SMRA8F7D5. Positions 4-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING416591.Tlet_1513.

Proteomic databases

PRIDEA8F7D5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV34069; ABV34069; Tlet_1513.
GeneID5608987.
KEGGtle:Tlet_1513.
PATRIC23933689. VBITheLet125395_1587.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycTLET416591:GI64-1550-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_THELT
AccessionPrimary (citable) accession number: A8F7D5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways