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A8F7D5

- FTHS_THELT

UniProt

A8F7D5 - FTHS_THELT

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Tlet_1513
Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTLET416591:GI64-1550-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Tlet_1513
OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000002016: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000068797Add
BLAST

Proteomic databases

PRIDEiA8F7D5.

Interactioni

Protein-protein interaction databases

STRINGi416591.Tlet_1513.

Structurei

3D structure databases

ProteinModelPortaliA8F7D5.
SMRiA8F7D5. Positions 4-551.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8F7D5-1 [UniParc]FASTAAdd to Basket

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MLSDIEIARS AKLEPVMNIA KNLSIPGDFL NSYGKFMAKI SHSFLKNLNI    50
RKGKLILVTA MTPTPAGEGK TTTSIGLSMA LNKIGHRSIV TLREPSLGPV 100
FGIKGGAAGG GYSQVLPMED INLHFTGDIH AVGTAHNLIS AVIDSHIRFG 150
NDLDIDLTKI TWPRAIDMND RALRNIVIAL GGHANGYPRE DGFVITAASE 200
IMAILCLSKD LQDLKNRVGN IVIGWSKNGK PVTVHELGIE GAIAVILKDA 250
INPNLVQTIE NTPAFIHGGP FANIAHGTNS IIATKMALGL SDYVVTESGF 300
GSDLGAEKFF DFVSPAADLK PSVAVIVATV RAIKYHGGVP LKDLENENLE 350
AIKKGIENLK IHIENVKKFN VPVVVALNRF ATDTERELDL VVNTVEKLGT 400
KISLNEAFAK GSEGAIDLAK KVIEVADESK FSPIYKWDSP VEEKIKILAT 450
EIYRAKDVSF SKEAITSLKQ IEKAGLSNLP VIVAKTQYSI SDDPSKLGAP 500
DGYVFNVRNF KLSSGAGFIV AISGEIMLMP GLGKKPNAVN IDIDEKGNIT 550
GLF 553
Length:553
Mass (Da):59,366
Last modified:November 13, 2007 - v1
Checksum:i4A5F59E26DF224C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34069.1.
RefSeqiWP_012003545.1. NC_009828.1.
YP_001471133.1. NC_009828.1.

Genome annotation databases

EnsemblBacteriaiABV34069; ABV34069; Tlet_1513.
GeneIDi5608987.
KEGGitle:Tlet_1513.
PATRICi23933689. VBITheLet125395_1587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34069.1 .
RefSeqi WP_012003545.1. NC_009828.1.
YP_001471133.1. NC_009828.1.

3D structure databases

ProteinModelPortali A8F7D5.
SMRi A8F7D5. Positions 4-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416591.Tlet_1513.

Proteomic databases

PRIDEi A8F7D5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV34069 ; ABV34069 ; Tlet_1513 .
GeneIDi 5608987.
KEGGi tle:Tlet_1513.
PATRICi 23933689. VBITheLet125395_1587.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TLET416591:GI64-1550-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-301 / DSM 14385 / TMO.

Entry informationi

Entry nameiFTHS_THELT
AccessioniPrimary (citable) accession number: A8F7D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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