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A8F7D5

- FTHS_THELT

UniProt

A8F7D5 - FTHS_THELT

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTLET416591:GI64-1550-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Tlet_1513
    OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
    Taxonomic identifieri416591 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000002016: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_1000068797Add
    BLAST

    Proteomic databases

    PRIDEiA8F7D5.

    Interactioni

    Protein-protein interaction databases

    STRINGi416591.Tlet_1513.

    Structurei

    3D structure databases

    ProteinModelPortaliA8F7D5.
    SMRiA8F7D5. Positions 4-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8F7D5-1 [UniParc]FASTAAdd to Basket

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    MLSDIEIARS AKLEPVMNIA KNLSIPGDFL NSYGKFMAKI SHSFLKNLNI    50
    RKGKLILVTA MTPTPAGEGK TTTSIGLSMA LNKIGHRSIV TLREPSLGPV 100
    FGIKGGAAGG GYSQVLPMED INLHFTGDIH AVGTAHNLIS AVIDSHIRFG 150
    NDLDIDLTKI TWPRAIDMND RALRNIVIAL GGHANGYPRE DGFVITAASE 200
    IMAILCLSKD LQDLKNRVGN IVIGWSKNGK PVTVHELGIE GAIAVILKDA 250
    INPNLVQTIE NTPAFIHGGP FANIAHGTNS IIATKMALGL SDYVVTESGF 300
    GSDLGAEKFF DFVSPAADLK PSVAVIVATV RAIKYHGGVP LKDLENENLE 350
    AIKKGIENLK IHIENVKKFN VPVVVALNRF ATDTERELDL VVNTVEKLGT 400
    KISLNEAFAK GSEGAIDLAK KVIEVADESK FSPIYKWDSP VEEKIKILAT 450
    EIYRAKDVSF SKEAITSLKQ IEKAGLSNLP VIVAKTQYSI SDDPSKLGAP 500
    DGYVFNVRNF KLSSGAGFIV AISGEIMLMP GLGKKPNAVN IDIDEKGNIT 550
    GLF 553
    Length:553
    Mass (Da):59,366
    Last modified:November 13, 2007 - v1
    Checksum:i4A5F59E26DF224C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000812 Genomic DNA. Translation: ABV34069.1.
    RefSeqiWP_012003545.1. NC_009828.1.
    YP_001471133.1. NC_009828.1.

    Genome annotation databases

    EnsemblBacteriaiABV34069; ABV34069; Tlet_1513.
    GeneIDi5608987.
    KEGGitle:Tlet_1513.
    PATRICi23933689. VBITheLet125395_1587.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000812 Genomic DNA. Translation: ABV34069.1 .
    RefSeqi WP_012003545.1. NC_009828.1.
    YP_001471133.1. NC_009828.1.

    3D structure databases

    ProteinModelPortali A8F7D5.
    SMRi A8F7D5. Positions 4-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416591.Tlet_1513.

    Proteomic databases

    PRIDEi A8F7D5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV34069 ; ABV34069 ; Tlet_1513 .
    GeneIDi 5608987.
    KEGGi tle:Tlet_1513.
    PATRICi 23933689. VBITheLet125395_1587.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci TLET416591:GI64-1550-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-301 / DSM 14385 / TMO.

    Entry informationi

    Entry nameiFTHS_THELT
    AccessioniPrimary (citable) accession number: A8F7D5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3