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A8F7D5

- FTHS_THELT

UniProt

A8F7D5 - FTHS_THELT

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTLET416591:GI64-1550-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Tlet_1513
OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000002016: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_1000068797Add
BLAST

Proteomic databases

PRIDEiA8F7D5.

Interactioni

Protein-protein interaction databases

STRINGi416591.Tlet_1513.

Structurei

3D structure databases

ProteinModelPortaliA8F7D5.
SMRiA8F7D5. Positions 4-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8F7D5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSDIEIARS AKLEPVMNIA KNLSIPGDFL NSYGKFMAKI SHSFLKNLNI
60 70 80 90 100
RKGKLILVTA MTPTPAGEGK TTTSIGLSMA LNKIGHRSIV TLREPSLGPV
110 120 130 140 150
FGIKGGAAGG GYSQVLPMED INLHFTGDIH AVGTAHNLIS AVIDSHIRFG
160 170 180 190 200
NDLDIDLTKI TWPRAIDMND RALRNIVIAL GGHANGYPRE DGFVITAASE
210 220 230 240 250
IMAILCLSKD LQDLKNRVGN IVIGWSKNGK PVTVHELGIE GAIAVILKDA
260 270 280 290 300
INPNLVQTIE NTPAFIHGGP FANIAHGTNS IIATKMALGL SDYVVTESGF
310 320 330 340 350
GSDLGAEKFF DFVSPAADLK PSVAVIVATV RAIKYHGGVP LKDLENENLE
360 370 380 390 400
AIKKGIENLK IHIENVKKFN VPVVVALNRF ATDTERELDL VVNTVEKLGT
410 420 430 440 450
KISLNEAFAK GSEGAIDLAK KVIEVADESK FSPIYKWDSP VEEKIKILAT
460 470 480 490 500
EIYRAKDVSF SKEAITSLKQ IEKAGLSNLP VIVAKTQYSI SDDPSKLGAP
510 520 530 540 550
DGYVFNVRNF KLSSGAGFIV AISGEIMLMP GLGKKPNAVN IDIDEKGNIT

GLF
Length:553
Mass (Da):59,366
Last modified:November 13, 2007 - v1
Checksum:i4A5F59E26DF224C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000812 Genomic DNA. Translation: ABV34069.1.
RefSeqiYP_001471133.1. NC_009828.1.

Genome annotation databases

EnsemblBacteriaiABV34069; ABV34069; Tlet_1513.
GeneIDi5608987.
KEGGitle:Tlet_1513.
PATRICi23933689. VBITheLet125395_1587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000812 Genomic DNA. Translation: ABV34069.1 .
RefSeqi YP_001471133.1. NC_009828.1.

3D structure databases

ProteinModelPortali A8F7D5.
SMRi A8F7D5. Positions 4-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416591.Tlet_1513.

Proteomic databases

PRIDEi A8F7D5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV34069 ; ABV34069 ; Tlet_1513 .
GeneIDi 5608987.
KEGGi tle:Tlet_1513.
PATRICi 23933689. VBITheLet125395_1587.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TLET416591:GI64-1550-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-301 / DSM 14385 / TMO.

Entry informationi

Entry nameiFTHS_THELT
AccessioniPrimary (citable) accession number: A8F7D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3