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A8F7B3

- KITH_THELT

UniProt

A8F7B3 - KITH_THELT

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Protein

Thymidine kinase

Gene
tdk, Tlet_1491
Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptor Reviewed prediction
Metal bindingi140 – 1401Zinc By similarity
Metal bindingi143 – 1431Zinc By similarity
Metal bindingi173 – 1731Zinc By similarity
Metal bindingi176 – 1761Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATP By similarity
Nucleotide bindingi83 – 864ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciTLET416591:GI64-1528-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:Tlet_1491
OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000002016: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Thymidine kinaseUniRule annotationPRO_1000057815Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi416591.Tlet_1491.

Structurei

3D structure databases

ProteinModelPortaliA8F7B3.
SMRiA8F7B3. Positions 2-180.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.
OrthoDBiEOG69D3J2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8F7B3-1 [UniParc]FASTAAdd to Basket

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MAGKLTLIVG PMYSGKTTEL LSYVEIYRLG RKKTIVFKPS LDNRYGVDCV    50
KTHAGVEVEA IAVEKSADAM KYIKQPVDAV FVDEVQFFDK DLVKIVRQLL 100
DQDVDIFCAG LDMTFKQNPF ETTMLLMSLA NEIIKKKAVC HICGEYNATL 150
TYKFVQDDSE IDIGGKEKYI AVCRDCYNKV ASKND 185
Length:185
Mass (Da):20,846
Last modified:November 13, 2007 - v1
Checksum:iB312AF036F86873E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34047.1.
RefSeqiYP_001471111.1. NC_009828.1.

Genome annotation databases

EnsemblBacteriaiABV34047; ABV34047; Tlet_1491.
GeneIDi5608237.
KEGGitle:Tlet_1491.
PATRICi23933645. VBITheLet125395_1565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV34047.1 .
RefSeqi YP_001471111.1. NC_009828.1.

3D structure databases

ProteinModelPortali A8F7B3.
SMRi A8F7B3. Positions 2-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416591.Tlet_1491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV34047 ; ABV34047 ; Tlet_1491 .
GeneIDi 5608237.
KEGGi tle:Tlet_1491.
PATRICi 23933645. VBITheLet125395_1565.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci TLET416591:GI64-1528-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-301 / DSM 14385 / TMO.

Entry informationi

Entry nameiKITH_THELT
AccessioniPrimary (citable) accession number: A8F7B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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