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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO) (Thermotoga lettingae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi488MagnesiumUniRule annotation1
Metal bindingi494MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciTLET416591:G1G9T-1446-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Tlet_1402
OrganismiPseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO) (Thermotoga lettingae)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePseudothermotoga
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003299121 – 710Polyribonucleotide nucleotidyltransferaseAdd BLAST710

Proteomic databases

PRIDEiA8F725

Interactioni

Protein-protein interaction databases

STRINGi416591.Tlet_1402

Structurei

3D structure databases

ProteinModelPortaliA8F725
SMRiA8F725
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini555 – 615KHUniRule annotationAdd BLAST61
Domaini625 – 688S1 motifUniRule annotationAdd BLAST64

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QUF Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A8F725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTWKREILG REFIVEHGKV AKQANGAVVA RIGDTTVLAT AVMSDSAVEG
60 70 80 90 100
IDFVPLTVEF QERFYAAGKI PGGFIKREGK PSEMAILSAR TIDRPIRPLF
110 120 130 140 150
PKHLRNEVQV VVTVISTDSV NTPDIVGVFA ASLALNISDI PFNGIVAAVR
160 170 180 190 200
VGLVDGKIVL FPTEDQLQKS LLDIVVAGTE DTITMVEGEA KEVSESQMLQ
210 220 230 240 250
ALLKAHDAIK QIIDFEKEIL SYFNIEKAQI AEKTLPEEIE KEFSQLLDGN
260 270 280 290 300
ELRERLLIQG KKARSNALSE YFKKIYEILE ARYGTEKIEE LSVLLKDKYE
310 320 330 340 350
EALKYKMRRI IVEEGTRLDM RKPKDIRPIT CETGLLPRVH GSALFTRGET
360 370 380 390 400
QSLGIVTLGA PMDEQIIDSL LEEGTKRFML HYNFPPFSTG EVKPLRGPSR
410 420 430 440 450
REIGHGHLAE RALKFVLPDE DRFPYTIRIV SEILESNGSS SMATVCSGSL
460 470 480 490 500
ALMDAGVPIS KHVAGVAMGL ILEKDSQIVL TDILGAEDHW GDMDFKVAGT
510 520 530 540 550
RDGITAFQMD CKVSGVSADL LERALNQAKE ARLYVLEKLY ETISKPRDTL
560 570 580 590 600
SKYAPVIKVI SIDPSKVAEI IGPGGKIIKA LIKDYDVKIS VDDLTGKVSV
610 620 630 640 650
IGGNEEKVDA AIEQINSILK EISVGDVFSG KVTRIEPFGV FVEISPGKVG
660 670 680 690 700
LLHQSKLITD LKTVKIGETM RVKVSNIDNL GRLQLEEFSD SPDHKHGEKR
710
SFKRHRKNDN
Length:710
Mass (Da):78,571
Last modified:November 13, 2007 - v1
Checksum:i3F9FF214FFCDB3AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000812 Genomic DNA Translation: ABV33959.1
RefSeqiWP_012003435.1, NC_009828.1

Genome annotation databases

EnsemblBacteriaiABV33959; ABV33959; Tlet_1402
KEGGitle:Tlet_1402

Similar proteinsi

Entry informationi

Entry nameiPNP_PSELT
AccessioniPrimary (citable) accession number: A8F725
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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