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A8F5X9

- PGK_THELT

UniProt

A8F5X9 - PGK_THELT

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371SubstrateUniRule annotation
    Binding sitei119 – 1191SubstrateUniRule annotation
    Binding sitei152 – 1521SubstrateUniRule annotation
    Binding sitei202 – 2021ATPUniRule annotation
    Binding sitei294 – 2941ATP; via carbonyl oxygenUniRule annotation
    Binding sitei325 – 3251ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi351 – 3544ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTLET416591:GI64-1023-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:Tlet_0997
    OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
    Taxonomic identifieri416591 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000002016: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Phosphoglycerate kinasePRO_1000058084Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi416591.Tlet_0997.

    Structurei

    3D structure databases

    ProteinModelPortaliA8F5X9.
    SMRiA8F5X9. Positions 2-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingUniRule annotation
    Regioni60 – 634Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227108.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8F5X9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKLTIKDID LSNKAVIMRV DFNVPIGKDG KVSDDTRITA ALPTIKYAVE    50
    KKAKVILLSH LGRPKGSFDP KYSLKPIAEH LKNISGLNVI FVPHVVGEEV 100
    KEAVKNMKVG DVLLLENTRF HPGEEKNDQE LAKAWAELAD IHVNDAFGTA 150
    HRAHASNVGI ANFIPSVAGF LMEKEIDFLN KVTYEPDHPY VVVLGGAKVS 200
    DKIGVITNLL NKADKLLIGG AMMFTFLKAQ GLKVGSSLVE NDKLDLAKQI 250
    LEQAKEKKVE IVLPVDAIVA QKIEAGVEKK TADLKDGIDD GWMGLDIGPK 300
    TIKVFEEALK NAKTVVWNGP MGVFEIEDFA GGTKAVAEMI AKIKGTTVIG 350
    GGDSAAAVAK FGLESAYSHV STGGGASLEF LEGKDLPGIR SIADKKK 397
    Length:397
    Mass (Da):42,699
    Last modified:November 13, 2007 - v1
    Checksum:i0E289354D1FA0B27
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000812 Genomic DNA. Translation: ABV33563.1.
    RefSeqiYP_001470627.1. NC_009828.1.

    Genome annotation databases

    EnsemblBacteriaiABV33563; ABV33563; Tlet_0997.
    GeneIDi5608831.
    KEGGitle:Tlet_0997.
    PATRICi23932575. VBITheLet125395_1040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000812 Genomic DNA. Translation: ABV33563.1 .
    RefSeqi YP_001470627.1. NC_009828.1.

    3D structure databases

    ProteinModelPortali A8F5X9.
    SMRi A8F5X9. Positions 2-396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416591.Tlet_0997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV33563 ; ABV33563 ; Tlet_0997 .
    GeneIDi 5608831.
    KEGGi tle:Tlet_0997.
    PATRICi 23932575. VBITheLet125395_1040.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227108.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci TLET416591:GI64-1023-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-301 / DSM 14385 / TMO.

    Entry informationi

    Entry nameiPGK_THELT
    AccessioniPrimary (citable) accession number: A8F5X9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3