Reviewed, UniProtKB/Swiss-Prot A8F5X7 (COMB_THELT)

Names and origin

Protein names

Recommended name:
    Probable 2-phosphosulfolactate phosphatase
    EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	Tlet_0995

Organism

Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO) [Complete proteome] [HAMAP]

Taxonomic identifier

416591 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the comB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000081394

Sequences

	Sequence		Length	Mass (Da)
	A8F5X7-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 3573ADD2C525D2AF	FASTA	224	25,015
	10 20 30 40 50 60 MIDVLFLPEP VSQQHVCVVV DVLRATSTIV TALANGARCV VPVRKIAEAK KRKAENILIC 70 80 90 100 110 120 GERKGIKPKG FDLGNSPIEY FTVKDKEVIL TTTNGTRAIS MINSQKLYAA CFLNLHAVIE 130 140 150 160 170 180 QLRNHDHVTI VCSGQKGKIA YEDVLCAGAI VYELNDKLTD GARISRELWK QSRRKDLSKL 190 200 210 220 LFESQHAQEL AEYGFSSDIT FCSQTDLYSI VPVFVEDRFI KQAP

References

[1]

"Complete sequence of Thermotoga lettingae TMO." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Bruce D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000812 Genomic DNA. Translation: ABV33561.1.
RefSeq	YP_001470625.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5608377.
GenomeReviews	Gene locus Tlet_0995 in contig CP000812_GR.
KEGG	tle:Tlet_0995.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A8F5X7. DFICSGY.
Family and domain databases
HAMAP	MF_00490. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COMB_THELT

Accession

Primary (citable) accession number: A8F5X7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 13, 2007
Last modified:	May 5, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)