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A8F5D0 (A8F5D0_THELT) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase HAMAP MF_00108
MEP cytidylyltransferase HAMAP MF_00108
Gene names
Name:ispD HAMAP MF_00108
Ordered Locus Names:Tlet_0798
OrganismThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO) [Complete proteome] [HAMAP]
Taxonomic identifier416591 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108

Sequence similarities

Belongs to the IspD family. HAMAP MF_00108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Site141Transition state stabilizer By similarity HAMAP MF_00108
Site211Transition state stabilizer By similarity HAMAP MF_00108
Site1511Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
Site2021Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

Sequence LengthMass (Da)Tools
A8F5D0 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: DD549F1647B96994

FASTA22325,255
        10         20         30         40         50         60 
MTVGIIMAAG TGNRFKSEIP KQFCMLGDKP VINYCLKSFE KSHLIDNCLI MVPTNWQEEV 

        70         80         90        100        110        120 
KKMIEGFRKP KWVLPGGATR HETSLIALEF LRDINPSVVV FHDAARPFLR VKLLNRVIEE 

       130        140        150        160        170        180 
AHLFGAATAA IPVNDTVVYA KDMFVNNYLS REGLYRIQTP QAFAFEIALN AFERFHANDG 

       190        200        210        220 
TEPVLLSGGK VRIVPGDLLC FKITYPDDLQ FAQFVYPTWN ELD

« Hide

References

[1]"Complete sequence of Thermotoga lettingae TMO."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Bruce D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-301 / DSM 14385 / TMO.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000812 Genomic DNA. Translation: ABV33364.1.
RefSeqYP_001470428.1. NC_009828.1.

3D structure databases

ProteinModelPortalA8F5D0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8F5D0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5609026.
GenomeReviewsGene locus Tlet_0798 in contig CP000812_GR.
KEGGtle:Tlet_0798.
PATRIC23932141. VBITheLet125395_0831.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG672839.
OMAREQQDFW.
ProtClustDBCLSK875736.

Enzyme and pathway databases

BioCycTLET416591:TLET_0798-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8F5D0_THELT
AccessionPrimary (citable) accession number: A8F5D0
Entry history
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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