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A8F596

- SYC_THELT

UniProt

A8F596 - SYC_THELT

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Protein

Cysteine--tRNA ligase

Gene
cysS, Tlet_0764
Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Zinc By similarity
Metal bindingi207 – 2071Zinc By similarity
Metal bindingi232 – 2321Zinc By similarity
Metal bindingi236 – 2361Zinc By similarity
Binding sitei267 – 2671ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciTLET416591:GI64-780-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligase (EC:6.1.1.16)
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name:
CysRS
Gene namesi
Name:cysS
Ordered Locus Names:Tlet_0764
OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000002016: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Cysteine--tRNA ligaseUniRule annotationPRO_1000090879Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi416591.Tlet_0764.

Structurei

3D structure databases

ProteinModelPortaliA8F596.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi29 – 3911"HIGH" regionUniRule annotationAdd
BLAST
Motifi264 – 2685"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0215.
HOGENOMiHOG000245250.
KOiK01883.
OMAiEPDEIAW.
OrthoDBiEOG6RVFXC.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00041. Cys_tRNA_synth.
InterProiIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR10890. PTHR10890. 1 hit.
PfamiPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00983. TRNASYNTHCYS.
SMARTiSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00435. cysS. 1 hit.

Sequencei

Sequence statusi: Complete.

A8F596-1 [UniParc]FASTAAdd to Basket

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MRFYNTLSKH IEEFKENEPG IVRMYVCGPT VYGLIHIGNA RPMVVFDALR    50
RYLEYRGYRV IMVQNFTDID DKIINKSIEF SVDFKDISET FIAEYWRDSM 100
ALGVRAPNFS PKTSDFVPEI INAIQNLIAK NHAYVVDGDV YFSVRSFPRY 150
GELSHRSIDE LKAGARIDLN EKKRDPLDFA LWKSAKPGEP YWKSPWGNGR 200
PGWHIECSVM STKLLGTTLD IHAGGEDLIF PHHENEKAQS EALTGKTFVK 250
YWLHNGMIKY TGDKMSKSTG NIFLLREALK KYGADALKIF FLSKHYRSPI 300
EFSEKALSSA AKAATRINET FLRFESEFSF AIPKQDSWIN EKRSIFIDSL 350
DDDFNTPRAL ALIFELVNSL NRAMDDGNER DALKIYHLLR REFCPVLGLF 400
DLPERADNRS IEELVKILID VRAELRAKKQ YELSDMIRSK LRKVGIELKD 450
MPQGTTYTFI KEV 463
Length:463
Mass (Da):53,437
Last modified:November 13, 2007 - v1
Checksum:iF578FE9B73F966CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV33330.1.
RefSeqiYP_001470394.1. NC_009828.1.

Genome annotation databases

EnsemblBacteriaiABV33330; ABV33330; Tlet_0764.
GeneIDi5608088.
KEGGitle:Tlet_0764.
PATRICi23932071. VBITheLet125395_0796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV33330.1 .
RefSeqi YP_001470394.1. NC_009828.1.

3D structure databases

ProteinModelPortali A8F596.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416591.Tlet_0764.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV33330 ; ABV33330 ; Tlet_0764 .
GeneIDi 5608088.
KEGGi tle:Tlet_0764.
PATRICi 23932071. VBITheLet125395_0796.

Phylogenomic databases

eggNOGi COG0215.
HOGENOMi HOG000245250.
KOi K01883.
OMAi EPDEIAW.
OrthoDBi EOG6RVFXC.

Enzyme and pathway databases

BioCyci TLET416591:GI64-780-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00041. Cys_tRNA_synth.
InterProi IPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR10890. PTHR10890. 1 hit.
Pfami PF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00983. TRNASYNTHCYS.
SMARTi SM00840. DALR_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00435. cysS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-301 / DSM 14385 / TMO.

Entry informationi

Entry nameiSYC_THELT
AccessioniPrimary (citable) accession number: A8F596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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