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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO) (Thermotoga lettingae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52NucleophileUniRule annotation1
Binding sitei110SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciTLET416591:G1G9T-712-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:Tlet_0694
OrganismiPseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO) (Thermotoga lettingae)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePseudothermotoga
Proteomesi
  • UP000002016 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000583101 – 245tRNA pseudouridine synthase AAdd BLAST245

Proteomic databases

PRIDEiA8F526

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi416591.Tlet_0694

Structurei

3D structure databases

ProteinModelPortaliA8F526
SMRiA8F526
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248673
KOiK06173
OMAiKGVHANN
OrthoDBiPOG091H010Q

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 2 hits
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit

Sequencei

Sequence statusi: Complete.

A8F526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRFMAIVSY DGTNFCGFQV QKDVRTVQGM FEQALERILK QRVITIAAGR
60 70 80 90 100
TDTGVHANGQ IVCFDCYLDI DEESMKNAMN ANLPDDIYVR KVVEVDKNFH
110 120 130 140 150
PRFDAKRRIY HYLIYNSQEP NLFIRNYAWW FPYKLNICKM REAAKFFEGE
160 170 180 190 200
HDFRSFMKSG DHRENTVRTI YRVRVLQLRG GIILIRVEGR SFLRRMVRNM
210 220 230 240
VGALVKVGVG EWKPEDISRV LELKDRSKAA VTAPPHGLYL YAVDF
Length:245
Mass (Da):28,674
Last modified:November 13, 2007 - v1
Checksum:iF174222454F9525B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000812 Genomic DNA Translation: ABV33260.1
RefSeqiWP_012002741.1, NC_009828.1

Genome annotation databases

EnsemblBacteriaiABV33260; ABV33260; Tlet_0694
KEGGitle:Tlet_0694

Similar proteinsi

Entry informationi

Entry nameiTRUA_PSELT
AccessioniPrimary (citable) accession number: A8F526
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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