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A8F3S6

- RUVC_THELT

UniProt

A8F3S6 - RUVC_THELT

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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene
ruvC, Tlet_0240
Organism
Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Magnesium By similarity
Metal bindingi67 – 671Magnesium By similarity
Metal bindingi140 – 1401Magnesium By similarity
Metal bindingi143 – 1431Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTLET416591:GI64-243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:Tlet_0240
OrganismiThermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
Taxonomic identifieri416591 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000002016: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Crossover junction endodeoxyribonuclease RuvCUniRule annotationPRO_1000057269Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416591.Tlet_0240.

Structurei

3D structure databases

ProteinModelPortaliA8F3S6.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012182.
KOiK01159.
OMAiRQVQEMV.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.

Sequencei

Sequence statusi: Complete.

A8F3S6-1 [UniParc]FASTAAdd to Basket

« Hide

MIIFGVDPGF GILGYGVLSV SGNSFQHVSH GTIQTEKQQN IALRLKVLYE    50
ELSNVIDNFK PSEIAMEKLF FSRNITTAIS VGEARGIVLL LAAQRNIPVF 100
EYTPHEIKKA VTGSGKASKK DVQQMIKILL NLKELPKPDD AADGLAIAWC 150
HCAVRNITRR FS 162
Length:162
Mass (Da):17,868
Last modified:November 13, 2007 - v1
Checksum:iC8E19634017EF0D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV32810.1.
RefSeqiYP_001469874.1. NC_009828.1.

Genome annotation databases

EnsemblBacteriaiABV32810; ABV32810; Tlet_0240.
GeneIDi5607881.
KEGGitle:Tlet_0240.
PATRICi23930975. VBITheLet125395_0259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000812 Genomic DNA. Translation: ABV32810.1 .
RefSeqi YP_001469874.1. NC_009828.1.

3D structure databases

ProteinModelPortali A8F3S6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416591.Tlet_0240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV32810 ; ABV32810 ; Tlet_0240 .
GeneIDi 5607881.
KEGGi tle:Tlet_0240.
PATRICi 23930975. VBITheLet125395_0259.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012182.
KOi K01159.
OMAi RQVQEMV.
OrthoDBi EOG6RG044.

Enzyme and pathway databases

BioCyci TLET416591:GI64-243-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-301 / DSM 14385 / TMO.

Entry informationi

Entry nameiRUVC_THELT
AccessioniPrimary (citable) accession number: A8F3S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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