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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Rickettsia massiliae (strain Mtu5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 37C4-typeUniRule annotationAdd BLAST26
Nucleotide bindingi117 – 124ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:RMA_1104
OrganismiRickettsia massiliae (strain Mtu5)
Taxonomic identifieri416276 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000001311 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000583441 – 425ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST425

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA8F2I3.
SMRiA8F2I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 37C4-typeUniRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000010093.
KOiK03544.
OMAiDIMYDLP.

Family and domain databases

Gene3Di3.30.50.30. 1 hit.
HAMAPiMF_00175. ClpX. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
IPR038366. Znf_CppX_C4_sf.
PANTHERiPTHR11262. PTHR11262. 2 hits.
PfamiView protein in Pfam
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.

Sequencei

Sequence statusi: Complete.

A8F2I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVETDKKEL ICSFCSKKQH EVKKLIAGPA VFICDECIDL CTDIMKEESK
60 70 80 90 100
VALKQITSSI PTPQKICGIL NDYVVGQDQA KKILAVAVYN HYKRLEYVQS
110 120 130 140 150
GNNDVELNKS NILLIGPTGS GKTLLAQTLA KILDVPFTMA DATSLTEAGY
160 170 180 190 200
VGEDVENILL RLLIAAEFNI AKAQKGIIYI DEVDKIARKS ENPSITRDVS
210 220 230 240 250
GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI LFICGGAFMG
260 270 280 290 300
IDSIITSRTN HSSIGFAANV NIDKEKNNSE ILKSLEIEDL TKFGLIPEFI
310 320 330 340 350
GRLPIVTTLD ELDNEALITI LTKPKNAIVK QYQKQFELDD AELVIDDSAL
360 370 380 390 400
EAIAEKALAK KTGARGLRSI LEHLLLDSMY KVAELKKQRV IITQEVVNGL
410 420
VEPIMTSLIS TKSNKKQPII EDIPA
Length:425
Mass (Da):46,647
Last modified:November 13, 2007 - v1
Checksum:iEB7FF3306DF43DBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000683 Genomic DNA. Translation: ABV85119.1.
RefSeqiWP_012153084.1. NC_009900.1.

Genome annotation databases

EnsemblBacteriaiABV85119; ABV85119; RMA_1104.
KEGGirms:RMA_1104.

Similar proteinsi

Entry informationi

Entry nameiCLPX_RICM5
AccessioniPrimary (citable) accession number: A8F2I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome