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A8F1J5

- SYL_RICM5

UniProt

A8F1J5 - SYL_RICM5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia massiliae (strain Mtu5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei605 – 6051ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRMAS416276:GJD3-610-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RMA_0602
    OrganismiRickettsia massiliae (strain Mtu5)
    Taxonomic identifieri416276 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000001311: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 835835Leucine--tRNA ligasePRO_1000057347Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi416276.RMA_0602.

    Structurei

    3D structure databases

    ProteinModelPortaliA8F1J5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi602 – 6065"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8F1J5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQIEQKWQH IWQEEKAFEV SNASSKPKYY VLEMLPYPSG KIHVGHVRNY    50
    SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIKNNSH PKKWTYSNIE 100
    NMKKQLKSMG FSYDWSREIN SCDPEYYKHE QKFFLELYER NLAYQKESLV 150
    NWDPVDNTVL ANEQVVDGRG WRSGAIVAKR YLKQWFLKIT DYAEELLNEI 200
    QNLKEWPEAV RSMQEKWIGK SIGANFHFKI KDNEETTIEV FSTKPETIFG 250
    ASFIGIAFNH PIIERLVSKT PEILAFITKC SHITGSSELE KAEKEGVFTG 300
    LFVIHPFDSN IVLPVIITNF VLMDYGTGAI FGCPANDERD HELAVKMNLS 350
    IKQVIKADMD VQKTAYTEDG ILVNSDFLNG LTSNEAKQEV IGEFEKLGIG 400
    KRSVNYRLKD WGISRQRFWG CPIPIIHCET CGIVPVPYKD LPVTLPDDVN 450
    FDGHGNPLDH HPSWKHVDCP KCDKPAVRET DTFDTFFESS WYFTRYCNSN 500
    AIEMTDKKAC DYWLPVDKYI GGIEHAVMHL LYARFFTKVM NEQKYVSVRE 550
    PFKGLFTQGM VLHATYKDEH NNWLYPEEVV KKGNEFFHKE SNNRVVQGRI 600
    EKMSKSKKNL IDLETMQEQY GADAIRLFVL SDSPPEKDLE WSASGIEGCS 650
    RFINKLEYMF KAIDSLKDDV NSEINKELNR LVHFTIKLVA EDIKHFALNR 700
    AIARMRELSN AISAEISKDK IDVKTVRHGF NVLVQLLNPF IPHITEEIWQ 750
    KLGNKKRLYN SSFPAFDESM LELDTYIMAV QVNGKLRDTY EFKTSVSEDE 800
    IKQVTVSLPK VQKFLEGKEP KKIILVPRKI VNILV 835
    Length:835
    Mass (Da):96,390
    Last modified:November 13, 2007 - v1
    Checksum:i93931E85257891BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000683 Genomic DNA. Translation: ABV84781.1.
    RefSeqiWP_012152756.1. NC_009900.1.
    YP_001499328.1. NC_009900.1.

    Genome annotation databases

    EnsemblBacteriaiABV84781; ABV84781; RMA_0602.
    GeneIDi5665934.
    KEGGirms:RMA_0602.
    PATRICi17895510. VBIRicMas83254_0738.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000683 Genomic DNA. Translation: ABV84781.1 .
    RefSeqi WP_012152756.1. NC_009900.1.
    YP_001499328.1. NC_009900.1.

    3D structure databases

    ProteinModelPortali A8F1J5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416276.RMA_0602.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV84781 ; ABV84781 ; RMA_0602 .
    GeneIDi 5665934.
    KEGGi rms:RMA_0602.
    PATRICi 17895510. VBIRicMas83254_0738.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RMAS416276:GJD3-610-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Lateral gene transfer between obligate intracellular bacteria: evidence from the Rickettsia massiliae genome."
      Blanc G., Ogata H., Robert C., Audic S., Claverie J.-M., Raoult D.
      Genome Res. 17:1657-1664(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mtu5.

    Entry informationi

    Entry nameiSYL_RICM5
    AccessioniPrimary (citable) accession number: A8F1J5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3